Table 1 Characteristics of all studies in the meta-analysis
Author | Study type | Sample size N: C | Mean age N: C | Gender M: F | Mean BMI N: C | Intervention | Outcome |
|---|---|---|---|---|---|---|---|
Jirarattanaphochai et al. | Double-Blind RCT | 120 (60:60) | 51 ± 12.7: 52 ± 10.9 | 51: 69 | 23.6 ± 2.3: 23.9 ± 2.9 | 40 mg parecoxib 30 min before surgery (intravenous) 40 mg every 12 h for 48 h after surgery (intravenous) | 1, 4 |
Karst et al. | Double-Blind RCT | 20 (12:8) | NP | NP | NP | Celecoxib 200 mg twice a day for 72 h starting on the evening before surgery (oral) | 2 |
Pookarnjanamorakot et al. | Double-Blind RCT | 47 (27:20) | 50.0 ± 13.1: 50.2 ± 12.2 | 15: 32 | NP | 40 mg piroxicam 1–3 h before surgery (oral) After surgery, 40 mg for 24 h, 20 mg for 48 h (oral) | 1, 2 |
Riest et al. | Double-Blind RCT | 160 (80:80) | NP | NP | NP | Parecoxib 40 mg twice a day throughout | 1, 3 |
Siribumrungwong et al. | Double-Blind RCT | 64 (32:32) | 58.2 ± 9.5: 55.6 ± 14 | 22: 42 | 26.4 ± 3.2: 26 ± 4.8 | 30 mg ketorolac 30 min before surgery (intravenous) | 1, 3, and 4 |
Double-Blind RCT | 64 (32:32) | 58 ± 8.6: 55.6 ± 14 | 24: 40 | 26 ± 3.6: 26 ± 4.8 | 40 mg parecoxib 30 min before surgery (intravenous) | 1, 3, and 4 | |
Rowe et al. | Double-Blind RCT | 30 (16:14) | NP | 18: 12 | NP | Indomethacin formulation 75 mg 2 h before surgery (oral) | 1, 2 |
Kelsaka et al. | Double-Blind RCT | 50 (25:25) | 44.1 ± 10.7: 47.9 ± 10.9 | 20: 30 | NP | Dexketoprofen 50 mg 10 min before surgery (intravenous) | 2 |
Cassinelli et al. | Double-Blind RCT | 25 (13:12) | 62.3 ± 10: 65.9±10.1 | NP | NP | 15 mg/0.5 mL (age > 65) or 30 mg/0.5 mL (age < 65) at the time of the surgical wound closure, 6 h postoperative and 12 h postoperative. | 1, 2 |
Kien et al. | RCT | 60 (30:30) | 44.93 ± 10.26: 48.23 ± 11.88 | 30: 30 | NP | 150 mg pregabalin, 200 mg of celecoxib 2 h before induction (oral) | 1, 2 |
Kim et al. | RCT | 80 (40:40) | 67.9 ± 7.6: 66.3 ± 10 | NP | NP | 75 mg pregabalin, 500 mg acetaminophen, 10 mg extended-release oxycodone 1 h before surgery and twice daily after surgery 200 mg celecoxib before surgery and once daily after surgery | 2 |
Raja et al. | Double-Blind RCT | 97 (47:50) | 49.7 ± 12.33: 51.6 ± 9.46 | 23: 74 | 26.4 ± 4.61: 25.8 ± 3.48 | 1 g paracetamol, 20 mg ketorolac, 75 mg pregabalin 4 h before surgery (oral) | 3, 4 |
Scott et al. | Double-Blind RCT | 40 (20:20) | 46 ± 7: 41 ± 9 | NP | NP | 15 mg ketorolac every 6 h (intravenous) | 1, 3 |
Double-Blind RCT | 40 (20:20) | 45 ± 10: 41 ± 9 | NP | NP | 30 mg ketorolac every 6 h (intravenous) | 1, 3 |