Table 3 Summary of findings
Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | |
|---|---|---|---|---|---|
Assumed risk | Intervention risk/risk difference | ||||
Conventional regimen | Restrictive regimen | ||||
Complications Overall rate | Randomized controlled trials | RR 0.46 (0.23 to 0.95) | 214 patients (3 studies) | ⊕ ⊕ ⊕ ⊝ Moderate1,2 | |
455 per 1000 | 210 per 1000 (105 to 432 per 1000) | ||||
Non-randomized studies | 645 patients (4 studies) | ⊕ ⊕ ⊝ ⊝ Low | |||
585 per 1000 | 433 per 1000 (310 to 602 per 1000) | RR 0.74 (0.53 to 1.03) | |||
Mortality | Randomized controlled trials | OR 0.51 (0.05 to 4.90) | 214 (3 studies) | ⊕ ⊕ ⊝ ⊝ Low2 | |
2 per 1000 | 1 fewer per 1000 (0 fewer to 10 fewer per 1000) | ||||
Non-randomized studies | ⊕ ⊕ ⊝ ⊝ Low | ||||
16 per 1000 | 5 fewer per 1000 (4 fewer to 22 fewer per 1000) | OR 0.30 (0.06 to 1.46) | 537 patients (3 patients | ||
Postoperative length of stay (PLOS) Scale: days | Randomized controlled trials | ||||
The mean PLOS ranged across control groups from 7 to 7 days | The mean PLOS in the intervention groups was 0.60 higher (0.75 lower to 1.95 higher) | MD 0.60 (0.75 to 1.95) | 62 patients (1 study) | ⊕ ⊝ ⊝ ⊝ Very low3 | |
Non-randomized studies | |||||
The mean PLOS ranged across control groups from 7 to 12 days | The mean PLOS in the intervention groups was 1.81 lower (3.27 lower to 0.35 lower) | MD − 1.81 (− 3.27 to − 0.35) | 439 patients (2 studies) | ⊕ ⊝ ⊝ ⊝ Very low3 | |