A comparative study on the effect of dopamine vs phenylephrine in improving the cutaneous analgesic effect of mexiletine in rats

Table 1 The percentages of maximum possible effect (%MPE), duration, and the area under the curves (AUCs) of mexiletine alone or co-administration of low dose mexiletine with dopamine or phenylephrine

Data are expressed as mean ± SD (n = 8 in each group). Compared with Mex 1.8 μmol, ^ap < 0.001, ^bp < 0.05; compared with Mex 1.8 μmol + Phe 0.0059 μmol, ^cp < 0.001, ^dp < 0.01, ^ep < 0.05; compared with Mex 1.8 μmol + Phe 0.0295 μmol, ^fp < 0.001, ^gp < 0.01; compared with Mex 1.8 μmol + Phe 0.1473 μmol, ^hp < 0.001, ⁱp < 0.05; compared with Mex 1.8 μmol + Dop 0.06 μmol, ^jp < 0.001, ^kp < 0.01. The data among the groups were analyzed using one-way ANOVA followed by Tukey’s honest significant difference (HSD) test for paired comparisons. Mex Mexiletine, Dop Dopamine, Phe Phenylephrine

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