Liberal fluid infusion group (PPV target 6–9%) (n=48) | Restrictive fluid infusion group (PPV target 13–16%) (n=49) | |
---|---|---|
Anaesthesia time (min) | 181±29 | 178±23 |
Operation time (min) | 139±27 | 135±22 |
Prone time (min) | 154±28 | 149±23 |
End-tidal sevoflurane concentration (%) | 2.0±0.3 | 1.9±0.4 |
Fluid infusion | ||
Baseline (ml) | 211±40 | 203±38 |
Number of boluses (n) | 7±2 | 5±2^^^ |
Total bolus volume (ml) | 1747±517 | 1099±395^^^ |
Blood loss (ml) | 150±67 | 162±70 |
Urine output (ml) | 302±163 | 163±63 ^^^ |
Body temperature (°C) | 36.5±0.2 | 36.5±0.3 |
PPV (%) | ||
Baseline | 14±2 | 15±2 |
Intraoperative time-weighted average | 8±1*** | 14±1^^^ |
Haematocrit (%) | ||
Baseline before anaesthesia | 39.9±1.1 | 40.2±1.6 |
During anaesthesia | ||
1 h | 36.2±1.0*** | 37.1±1.2***^ |
2 h | 35.6±1.1*** | 36.9±1.1***^^ |
End of surgery | 35.4±1.3*** | 36.8±1.1***^^ |
PaO2 (mmHg) | ||
Baseline before anaesthesia | 85.1±9.7 | 85.9±11.2 |
During anaesthesia | ||
1 h | 297.1±63.4*** | 297.6±55.9*** |
2 h | 294.4±61.9*** | 300.8±49.8*** |
End of surgery | 290.5±60.2*** | 292.8±46.4*** |
PaCO2 (mmHg) | ||
Baseline before anaesthesia | 36.3±2.4 | 36.1±2.4 |
During anaesthesia | ||
1 h | 36.9±2.4 | 37.3±1.5** |
2 h | 37.0±2.0 | 36.6±1.1 |
End of surgery | 37.2±1.3 ** | 36.3±1.4 |
Lactate (mmol•L–1) | ||
Baseline before anaesthesia | 0.9±0.2 | 0.8±0.3 |
During anaesthesia | ||
1 h | 1.2±0.2*** | 1.1±0.3*** |
2 h | 1.2±0.2*** | 1.1±0.3*** |
End of surgery | 1.2±0.2*** | 1.1±0.3*** |
Patients needed vasopressors (n) | 39 | 40 |
Total ephedrine dose (mg) | 3±4 | 3±3 |
Total phenylephrine dose (μg) | 29±36 | 36±39 |