Table 3 Secondary outcomes in patients randomly allocated to high-flow nasal oxygen therapy (HFNT) or standard oxygen therapy (SOT) during sedation for transcatheter aortic valve replacement. Values are number (proportion) or median (IQR [range])

pO₂ percentage change from baseline to 30 min

9.62 (− 8.04, 30.57 [− 36.09 to 127.27])

 − 2.73 (− 10.82, 5.71[− 26.51 to 97.19])

0.171

pCO₂ percentage change from baseline to 30 min

4.84 (− 3.71, 17.86 [− 16.13 to 59.46])

5.00 (− 2.74, 14.95 [− 15.52 to 51.02])

0.802

Number of desaturations

0.027

0

31 (86.1%)

24 (66.7%)

1

4 (11.1%)

3 (8.3%)

 > 1

1 (2.8%)

9 (25.0%)

Cerebral desaturation*

0.221

Yes

4 (11.8%)

9 (25.0%)

No

30 (88.2%)

27 (75.0%)

Number of times patient reaches for oxygen delivery device

0.003

0

34 (94.4%)

23 (63.9%)

 ≥ 1

2 (5.6%)

13 (36.1%)

Comfort level

 < 0.001

Excellent

17 (48.3%)

3 (8.6%)

Good

13 (37.1%)

10 (28.6%)

Fair

5 (14.3%)

19 (54.3%)

Poor

0

3 (8.6%)

Throat dryness

0.484

Severe

1 (2.9%)

1 (2.9%)

Moderate

10 (28.6%)

15 (42.9%)

Slight

7 (20.0%)

8 (22.9%)

Not at all

17 (48.6%)

11 (31.4%)

Abdominal bloating

0.360

Severe

0

0

Moderate

0

2 (5.7%)

Slight

3 (8.6%)

1 (2.9%)

Not at all

32 (91.4%)

32 (91.4%)

PACU oxygen therapy

0.123

Yes

14 (40.0%)

22 (61.1%)

Discharge from PACU with oxygen therapy

0.778

Yes

7 (20.0%)

9 (25.0%)

PACU stay; min

54.00 (36.25–77.0 [8.0–210.0])

52.50 (39.50–86.25 [15.0–252.0])

0.694

Duration of oxygen therapy; min

119.00 (102.00–170.00 [0–2237.0])

151.00 (111.00–271.00 [78.0–7091.0])

0.209

Hospital stay; days

3.09 (2.24–6.29 [1.33–18.2])

3.55 (2.20–5.49 [1.05–18.4])

0.936

Duration of procedure; min

117.00 (102.50–131.00 [74.0–151.0])

115.50 (101.00–135.50 [73.0–218.0])

0.954