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Table 1 The characteristics for included articles

From: The safety of perioperative dexamethasone with antiemetic dosage in surgical patients with diabetes mellitus: a systematic review and meta-analysis

Author

Publication time

Design

Groups

Intervention

Outcomes

Jadad/ NOS score

Tien et al. (Tien et al. 2016)

2016

RCT

Dex (n = 20)

Dex 8 mg at induction

Maximal glucose change, glucose levels, insulin required

7

C (n = 24)

Ondansetron 4 mg at induction

Nazar et al. (Nazar et al. 2009)

2009

RCT

Dex (n = 15)

Dex 8 mg at induction

Maximal glucose change, glucose levels

4

C (n = 15)

Saline at induction

Corcoran et al. (Corcoran et al. 2021a)

2020

RCT

Dex (4) (n = 22)

Dex 4 mg at induction

Maximal glucose change, glucose levels, wound infection and dehiscence

5

Dex (8) (n = 19)

Dex 8 mg at induction

C (n = 22)

Saline at induction

Backes et al. (Backes et al. 2013)

2013

RCT

Dex (n = 41)

Dex 10 mg at induction

Maximal glucose change, maximal glucose level

6

C (n = 37)

No treatment

Nazar et al. (Nazar et al. 2011)

2011

RCT

Dex (n = 15)

Dex 8 mg at induction

Maximal glucose, glucose levels

4

C (n = 15)

Saline at induction

Purushothaman et al. (Purushothaman et al. 2018)

2018

RCT

Dex (4) (n = 45)

Dex 4 mg pre-anesthesia

Maximal glucose, glucose levels

4

Dex (8) (n = 45)

Dex 8 mg pre-anesthesia

C (n = 45)

Saline pre-anesthesia

Zhang et al. (Zhang et al. 2014)

2014

RCT

Dex (n = 10)

Dex 10 mg pre-anesthesia

Maximal glucose change, glucose levels

3

C (n = 10)

Saline pre-anesthesia

Shang et al. (Shang et al. 2022)

2022

RCT

Dex (n = 45)

Dex 0.11 mg/kg post-induction

Glucose levels, insulin required, wound infection and dehiscence

4

C (n = 45)

Saline post-induction

Corcoran et al. (Corcoran et al. 2021b)

2021

RCT

Dex (n = 583)

Dex 8 mg at induction

Wound infection

7

C (n = 571)

Saline at induction

Wasfie et al. (Wasfie et al. 2018)

2018

Cohort study

Dex (n = 119)

Dex intraoperative

Glucose levels

7

C (n = 235)

No treatment

Herbst et al. (Herbst et al. 2020)

2020

Cohort study

Dex (n = 626)

Dex perioperative

Maximal glucose, glucose levels

7

C (n = 520)

No treatment

Godshaw et al. (Godshaw et al. 2019)

2019

Cohort study

Dex (n = 428)

Dex 6 or 12 mg pre-incision

Glucose levels, infection

6

C (n = 229)

No treatment

Allen et al. (Allen et al. 2020)

2020

Cohort study

Dex (n = 92)

Dex 8 mg pre-incision

Maximal glucose,glucose levels, insulin required

7

C (n = 193)

No treatment

Egan et al. (Egan et al. 2019)

2019

Cohort study

Dex (n = 17)

Dex 4 or 10 mg intraoperative

Glucose levels, Insulin requirement, wound infection and dehiscence

6

C (n = 104)

No treatment

Harding et al. (Harding et al. 2021)

2021

Cohort study

Dex (n = 173)

Dex 4–10 mg intraoperative

Hyperglycemia, glucose levels, wound infection

7

C (n = 55)

No treatment

O’Connell et al. (O'Connell et al. 2018)

2018

Cohort study

Dex (n = 77)

Dex intraoperative

Glucose levels

7

C (n = 161)

No treatment

  1. Dex dexmethosone, C control, RCT randomized controlled trial