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Table 3 Univariate and multivariate predictors of hepatic failure

From: Early postoperative serum aspartate aminotransferase for prediction of post-hepatectomy liver failure

Variable

Univariate

Multivariate

OR (95% CI)

p value

OR (95% CI)

p value

Age (year)

0.999(0.97–1.03)

0.998

  

Gender

 Male

1

 

1

 

 Female

0.443(0.21–0.95)

0.037

0.572(0.17–1.94)

 0.371

Comorbidity

 DM

0.868(0.35–2.15)

0.760

  

 HT

0.468(0.21–1.06)

0.069

  

 DLP

0.227(0.05–0.96)

0.044

0.634(0.13–3.16)

0.579

 HBV

1.139(0.50–2.58)

0.756

  

 HCV

0.754(0.18–3.22)

0.703

  

Smoking, n = 881

 No

1

 

1

 

 Yes

2.714(1.28–5.72)

0.009

1.822(0.57–5.80)

0.310

Preoperative neoadjuvant

 No

1

   

 Yes

1.564(0.66–3.70)

0.309

  

Pre-op diagnosis

 Benign

1

   

 Malignant

1.976(0.90–4.34)

0.090

  

ICG R15, n = 537

1.032(1.00–1.06)

0.031

1.091(1.03–1.15)

0.002

Type operation

 Minor

1

 

1

 

 Major

12.481(5.05–30.83)

0.000

5.964(1.70–20.96)

0.005

Operative time (h), n = 877

1.568(1.37–1.79)

0.000

  

Blood loss (ml), n = 877

1.032(1.02–1.05)

0.000

1.019(1.00–1.04)

0.049

Clamp time (min), n = 620

1.013(1.00–1.02)

0.014

  

Pre-op creatinine (mg/dL), n = 796

0.691(0.21–2.32)

0.550

  

ALBI score, n = 819

 ALBI grade I (≤− 2.60)

1

   

 ALBI grade II (> − 2.60 to ≤ − 1.39)

0.248(0.03–2.07)

0.198

  

 ALBI grade 3 (> − 1.39)

0.747(0.09–6.21)

0.788

  

Pre-op platelet, n = 830

1.078(0.72–1.61)

0.711

  

POD1 liver function data

 TB (mg/dL) day 1, n = 797

1.062(1.01–1.12)

0.019

  

 ALP (U/L) day 1, n = 797

3.036(1.93–4.78)

0.000

  

 Alb (g/L) day 1, n = 825

0.995(0.91–1.09)

0.916

  

 INR day 1, n = 768

2.645(2.04–3.42)

0.000

2.025(1.36–3.00)

0.000

POD1 ALT(U/L), n = 784

 ALT ≤ 270

1

   

 ALT > 270

6.539(2.78–15.38)

0.000

  

POD1 AST (U/L), n = 796

 AST ≤ 260

1

 

1

 

 AST > 260

13.980(4.20–46.49)

0.000

5.346(1.37–20.83)

0.016

  1. DM diabetes mellitus, HT hypertension, DLP dyslipidemia, HBV hepatitis B virus, HCV hepatitis C virus, ALBI albumin-bilirubin, ICG R15 indocyanine green retention test at 15 min, TB total bilirubin, ALT alanine aminotransferase, AST aspartate aminotransferase, Alb albumin, INR international normalized ratio