Skip to main content

Table 4 Postoperative outcome

From: Perioperative statin medication impairs pulmonary outcome after abdomino-thoracic esophagectomy

Variable All patients Propensity score-matched patients
Statin ( −) patients (n = 91) Statin ( +) patients (n = 26) p value psmStatin ( −) patients (n = 52) psmStatin ( +) patients (n = 26) p value
PO hospital stay
 Total [d]a 17 (9–141) 25 (11–75) 0.0068 16.5 (9–141) 25 (11–75) 0.0185
 Initial PO stay on ICU [d]a 4 (1–76) 6 (2–58) 0.0729 5 (1–76) 6 (2–58) 0.2556
 Return to ICU [n patients] 17 (18.7%) 3 (11.5%) 0.5578 8 (15.4%) 3 (11.5%) 0.7429
 Cumulative PO stay on ICU [d]a 5 (1–84) 11.5 (2–58) 0.0221 5 (1–84) 11.5 (2–58) 0.0612
Initial postoperative extubation [h] 0 (0–11) 0 (0–4) 0.8171 0 (0–11) 0 (0–4) 0.8666
Cumulative perioperative mechanical ventilation [h] 12.6 (4.8–2280) 13.5 (5.2–788.3) 0.5184 12.7 (5.3–876.9) 13.5 (5.2–788.3) 0.6146
Pneumoniab 30 (33.0%) 17 (65.4%) 0.0057 20 (38.5%) 17 (65.4%) 0.0317
Pneumonia diagnosis on POD 6 (1–25) 4 (1–18) 0.1390 6 (1–25) 4 (1–18) 0.2507
Tracheotomy 13 (14.3%) 7 (26.9%) 0.1462 10 (19.2%) 7 (26.9%) 0.5619
Extubation in the operating room 22 (24.2%) 6 (23.1%) 1 12 (23.1%) 6 (23.1%) 1
Initial extubation during the first 12 h postoperatively 75 (82.4%) 21 (80.8%) 0.7808 42 (80.8%) 21 (80.8%) 1
Re-intubationc 22 (24.2%) 10 (38.5%) 0.2111 15 (28.9%) 10 (38.5%) 0.4453
Perioperative oxygenation index < 300 mm Hg [n patients]d
 First intraoperative 21 (23.1%) 6 (23.1%) 1 14 (26.9%) 6 0.7891
 POD 0 (on arrival at ICU) 32 (35.2%) 8 (30.8%) 0.3429 22 (42.3%) 8 0.4594
 POD 1 27 (29.7%) 10 (38.5%) 0.4743 19 (36.5%) 10 1
 POD 2 37 (40.7%) 14 (53.9%) 0.2667 20 (38.5%) 14 0.2312
 POD 3 28 (30.8%) 14 (53.9%) 0.0382 17 (32.7%) 14 0.0889
 POD 4 19* (21.1%) 12 (46.2%) 0.0215 10* (19.6%) 12 0.0187
 POD 5 17* (18.9%) 10 (38.5%) 0.0624 11* (21.6%) 10 0.1752
 POD 6 21* (23.3%) 7* (28.0%) 0.6087 12* (23.5%) 7* 0.7795
 POD 7 19* (21.1%) 10* (40.0%) 0.0695 14* (27.5%) 10* 0.3015
 POD 8 20* (22.2%) 10* (40.0%) 0.1201 12* (23.5%) 10* 0.1799
 POD 9 19* (21.1%) 7* (28.0%) 0.5890 12* (23.5%) 7* 0.7795
 POD 10 17* (18.9%) 7** (29.2%) 0.2730 10* (19.6%) 7** 0.3860
Re-do (revision) surgery during POD 1–30 12 (13.2%) 9 (34.6%) 0.2278 10 (19.2%) 6 (34.6%) 0.7690
Anastomotic complicationse 18 (19.8%) 6 (23.1%) 0.7842 11 (21.2%) 6 (23.1%) 1
PO 30-day mortality [n] 6 (6.6%) 3 (11.5%) 0.4139 5 (9.6%) 3 (11.5%) 1
  1. Data are given in median and minimum to maximum ranges or n (%). aPatients who suffered from in-hospital mortality were excluded from the analysis of postoperative length of stays. bOverall pneumonia rate, irrespectively from re-do surgery. cRe-intubation due to acute respiratory insufficiency excluding re-intubations due to re-do (revision) surgery. dIrrespectively from re-do surgery; patients who died during POD 0–10 were excluded from the analysis upon their death: asterisks (* and **) indicate the number of deaths on the respective postoperative day. eAnastomotic complications, including insufficiency and/or gastric tube necrosis requiring therapy (stent, endo-vacuum therapy, or re-do surgery). psm Propensity score matched; PO Postoperative, ICU Intensive care unit, includes medium care unit; POD Postoperative day