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Table 4 Postoperative outcome

From: Perioperative statin medication impairs pulmonary outcome after abdomino-thoracic esophagectomy

Variable

All patients

Propensity score-matched patients

Statin ( −) patients (n = 91)

Statin ( +) patients (n = 26)

p value

psmStatin ( −) patients (n = 52)

psmStatin ( +) patients (n = 26)

p value

PO hospital stay

 Total [d]a

17 (9–141)

25 (11–75)

0.0068

16.5 (9–141)

25 (11–75)

0.0185

 Initial PO stay on ICU [d]a

4 (1–76)

6 (2–58)

0.0729

5 (1–76)

6 (2–58)

0.2556

 Return to ICU [n patients]

17 (18.7%)

3 (11.5%)

0.5578

8 (15.4%)

3 (11.5%)

0.7429

 Cumulative PO stay on ICU [d]a

5 (1–84)

11.5 (2–58)

0.0221

5 (1–84)

11.5 (2–58)

0.0612

Initial postoperative extubation [h]

0 (0–11)

0 (0–4)

0.8171

0 (0–11)

0 (0–4)

0.8666

Cumulative perioperative mechanical ventilation [h]

12.6 (4.8–2280)

13.5 (5.2–788.3)

0.5184

12.7 (5.3–876.9)

13.5 (5.2–788.3)

0.6146

Pneumoniab

30 (33.0%)

17 (65.4%)

0.0057

20 (38.5%)

17 (65.4%)

0.0317

Pneumonia diagnosis on POD

6 (1–25)

4 (1–18)

0.1390

6 (1–25)

4 (1–18)

0.2507

Tracheotomy

13 (14.3%)

7 (26.9%)

0.1462

10 (19.2%)

7 (26.9%)

0.5619

Extubation in the operating room

22 (24.2%)

6 (23.1%)

1

12 (23.1%)

6 (23.1%)

1

Initial extubation during the first 12 h postoperatively

75 (82.4%)

21 (80.8%)

0.7808

42 (80.8%)

21 (80.8%)

1

Re-intubationc

22 (24.2%)

10 (38.5%)

0.2111

15 (28.9%)

10 (38.5%)

0.4453

Perioperative oxygenation index < 300 mm Hg [n patients]d

 First intraoperative

21 (23.1%)

6 (23.1%)

1

14 (26.9%)

6

0.7891

 POD 0 (on arrival at ICU)

32 (35.2%)

8 (30.8%)

0.3429

22 (42.3%)

8

0.4594

 POD 1

27 (29.7%)

10 (38.5%)

0.4743

19 (36.5%)

10

1

 POD 2

37 (40.7%)

14 (53.9%)

0.2667

20 (38.5%)

14

0.2312

 POD 3

28 (30.8%)

14 (53.9%)

0.0382

17 (32.7%)

14

0.0889

 POD 4

19* (21.1%)

12 (46.2%)

0.0215

10* (19.6%)

12

0.0187

 POD 5

17* (18.9%)

10 (38.5%)

0.0624

11* (21.6%)

10

0.1752

 POD 6

21* (23.3%)

7* (28.0%)

0.6087

12* (23.5%)

7*

0.7795

 POD 7

19* (21.1%)

10* (40.0%)

0.0695

14* (27.5%)

10*

0.3015

 POD 8

20* (22.2%)

10* (40.0%)

0.1201

12* (23.5%)

10*

0.1799

 POD 9

19* (21.1%)

7* (28.0%)

0.5890

12* (23.5%)

7*

0.7795

 POD 10

17* (18.9%)

7** (29.2%)

0.2730

10* (19.6%)

7**

0.3860

Re-do (revision) surgery during POD 1–30

12 (13.2%)

9 (34.6%)

0.2278

10 (19.2%)

6 (34.6%)

0.7690

Anastomotic complicationse

18 (19.8%)

6 (23.1%)

0.7842

11 (21.2%)

6 (23.1%)

1

PO 30-day mortality [n]

6 (6.6%)

3 (11.5%)

0.4139

5 (9.6%)

3 (11.5%)

1

  1. Data are given in median and minimum to maximum ranges or n (%). aPatients who suffered from in-hospital mortality were excluded from the analysis of postoperative length of stays. bOverall pneumonia rate, irrespectively from re-do surgery. cRe-intubation due to acute respiratory insufficiency excluding re-intubations due to re-do (revision) surgery. dIrrespectively from re-do surgery; patients who died during POD 0–10 were excluded from the analysis upon their death: asterisks (* and **) indicate the number of deaths on the respective postoperative day. eAnastomotic complications, including insufficiency and/or gastric tube necrosis requiring therapy (stent, endo-vacuum therapy, or re-do surgery). psm Propensity score matched; PO Postoperative, ICU Intensive care unit, includes medium care unit; POD Postoperative day
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Perioperative Medicine

ISSN: 2047-0525