Skip to main content

Table 2 Univariate logistic regression analysis. OR, odds ratio. 95% CI, 95% confidence interval

From: The Marsden Morbidity Index: the derivation and validation of a simple risk index scoring system using cardiopulmonary exercise testing variables to predict morbidity in high-risk patients having major cancer surgery

Variable Morbidity
n = 540
No morbidity
n = 858
OR (95% CI) p-value
  Median (range) Median (range)   
Age (years)
 Mean (SD) 68.36 (9.63) 66.79 (12.38) 1.01 (1.00–1.02) 0.013
 Median (IQR) 68 (65–78) 68 (65–78)   
BMI
 Mean (SD) 27.79 (8.02) 28.10 (3.97)   
 Median (IQR) 29 (18–35) 28 (26–32) 0.99 (0.97–1.01) 0.347
AT
 Mean (SD) 9.62 (2.00) 11.53 (1.64)   
 Median (IQR) 9.6 (7.8–11.8) 11.1 (10.4–12.6) 0.54 (0.50–0.59) < 0.001
VO2 max
 Mean (SD) 13.20 (4.35) 19.57 (5.11)   
 Median (IQR) 12.9 (9.9–14.6) 18.9 (15.8–23.4) 0.71 (0.69–0.74) < 0.001
AT VE/VCO2
 Mean (SD) 38.19 (3.70) 34.09 (4.03)   
 Median (IQR) 36 (32–38) 35 (30–37) 1.32 (1.28–1.37) < 0.001
Oxygen pulse
 Mean (SD) 9.46 (2.80) 9.75 (3.11)   
 Median (IQR) 8.9 (6.7–13.2) 10.2 (6.6–13.2) 0.97 (0.93–1.00) 0.080
Possum score
 Mean (SD) 33.32 (6.10) 34.41 (9.97)   
 Median (IQR) 34 (32–34) 34 (28–35) 0.99 (0.97–1.00) 0.023
  n(%) n(%)   
Age group
 ≤ 50 years 46 (28) 118 (72) 1 0.014
 51–70 years 289 (40) 433 (60) 1.71 (1.18–2.48) 0.005
 > 70 years 205 (40) 307 (60) 1.71 (1.17–2.51) 0.006
Gender
 Female 267 (38) 427 (62) 1 0.907
 Male 273 (39) 431 (61) 1.01 (0.82–1.26)  
BMI standard categories
 < 18.5 171 (84) 32 (16) 29.00 (16.91–49.59) < 0.001
 18.5–24.99 31 (16) 168 (84) 1 < 0.001
 ≥ 25.0 338 (34) 658 (66) 2.78 (1.86–4.17) < 0.001
Surgery type
 Robotic/laparoscopic 28 (8) 328 (92) 1 < 0.001
 Open 512 (49) 530 (51) 11.32 (7.55–16.96)  
ASA score
 ASA 1 9 (41) 13 (59) 1 < 0.001
 ASA 2 475 (44) 601 (56) 1.14 (0.48–2.69) 0.762
 ASA 3 and 4 56 (19) 244 (81) 0.33 (0.14–0.81) 0.016
WHO category
 0 210 (29) 525 (71) 1 < 0.001
 ≥ 1 330 (50) 333 (50) 2.48 (1.99–3.09)  
Arrhythmia
 No 439 (35) 807 (65) 1  
 Yes 101 (66) 51 (34) 3.64 (2.55–5.20) < 0.001
Documented cirrhosis
 No 496 (38) 811 (62) 1  
 Yes 44 (48) 47 (52) 1.53 (1.00–2.34) 0.050
Congestive cardiac failure
 No 506 (37) 852 (63) 1 < 0.001
 Yes 34 (85) 6 (15) 9.54 (3.98–22.88)  
Diabetic status
 Negative 400 (39) 634 (61) 1 0.300
 Non-insulin 123 (40) 183 (60) 1.07 (0.82–1.38) 0.634
 Insulin dependent 17 (29) 41 (71) 0.66 (0.37–1.17) 0.155
COPD
 No 247 (29) 619 (71) 1 < 0.001
 Yes 293 (55) 243 (45) 3.02 (2.40–3.76)  
Previous cardiac event
 No 302 (31) 673 (69) 1 < 0.001
 Yes 238 (56) 185 (44) 2.87 (2.27–3.63)  
Prior TIA/stroke
 No 446 (35) 823 (65) 1 < 0.001
 Yes 94 (73) 35 (27) 4.96 (3.31–7.43)  
Chronic renal impairment
 No 323 (28) 824 (72) 1 < 0.001
 Yes 217 (86) 34 (14) 16.28 (11.09–23.90)  
Number of procedures
 1 252 (32) 530 (68) 1 < 0.001
 ≥ 2 288 (47) 328 (53) 1.85 (1.48–2.30)  
Cancer stage
 Primary 474 (38) 760 (62) 1 < 0.001
 Local nodal metastases 45 (32) 95 (68) 0.76 (0.52–1.10) 0.148
 Distant metastases 20 (87) 3 (13) 10.69 (3.16–36.17) < 0.001
Surgical categories
 Hepatobiliary 85 (37) 143 (63)   
 Urology 141 (41) 199 (59)   
 General surgery 129 (39) 201 (61)   
 Colorectal/lower GI 30 (25) 88 (75)   
 Upper GI 99 (42) 135 (58)   
 Gynaecological 52 (38) 86 (62)   
 Sarcoma 3 (33) 6 (67)