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Table 2 Univariate logistic regression analysis. OR, odds ratio. 95% CI, 95% confidence interval

From: The Marsden Morbidity Index: the derivation and validation of a simple risk index scoring system using cardiopulmonary exercise testing variables to predict morbidity in high-risk patients having major cancer surgery

Variable

Morbidity

n = 540

No morbidity

n = 858

OR (95% CI)

p-value

 

Median (range)

Median (range)

  

Age (years)

 Mean (SD)

68.36 (9.63)

66.79 (12.38)

1.01 (1.00–1.02)

0.013

 Median (IQR)

68 (65–78)

68 (65–78)

  

BMI

 Mean (SD)

27.79 (8.02)

28.10 (3.97)

  

 Median (IQR)

29 (18–35)

28 (26–32)

0.99 (0.97–1.01)

0.347

AT

 Mean (SD)

9.62 (2.00)

11.53 (1.64)

  

 Median (IQR)

9.6 (7.8–11.8)

11.1 (10.4–12.6)

0.54 (0.50–0.59)

< 0.001

VO2 max

 Mean (SD)

13.20 (4.35)

19.57 (5.11)

  

 Median (IQR)

12.9 (9.9–14.6)

18.9 (15.8–23.4)

0.71 (0.69–0.74)

< 0.001

AT VE/VCO2

 Mean (SD)

38.19 (3.70)

34.09 (4.03)

  

 Median (IQR)

36 (32–38)

35 (30–37)

1.32 (1.28–1.37)

< 0.001

Oxygen pulse

 Mean (SD)

9.46 (2.80)

9.75 (3.11)

  

 Median (IQR)

8.9 (6.7–13.2)

10.2 (6.6–13.2)

0.97 (0.93–1.00)

0.080

Possum score

 Mean (SD)

33.32 (6.10)

34.41 (9.97)

  

 Median (IQR)

34 (32–34)

34 (28–35)

0.99 (0.97–1.00)

0.023

 

n(%)

n(%)

  

Age group

 ≤ 50 years

46 (28)

118 (72)

1

0.014

 51–70 years

289 (40)

433 (60)

1.71 (1.18–2.48)

0.005

 > 70 years

205 (40)

307 (60)

1.71 (1.17–2.51)

0.006

Gender

 Female

267 (38)

427 (62)

1

0.907

 Male

273 (39)

431 (61)

1.01 (0.82–1.26)

 

BMI standard categories

 < 18.5

171 (84)

32 (16)

29.00 (16.91–49.59)

< 0.001

 18.5–24.99

31 (16)

168 (84)

1

< 0.001

 ≥ 25.0

338 (34)

658 (66)

2.78 (1.86–4.17)

< 0.001

Surgery type

 Robotic/laparoscopic

28 (8)

328 (92)

1

< 0.001

 Open

512 (49)

530 (51)

11.32 (7.55–16.96)

 

ASA score

 ASA 1

9 (41)

13 (59)

1

< 0.001

 ASA 2

475 (44)

601 (56)

1.14 (0.48–2.69)

0.762

 ASA 3 and 4

56 (19)

244 (81)

0.33 (0.14–0.81)

0.016

WHO category

 0

210 (29)

525 (71)

1

< 0.001

 ≥ 1

330 (50)

333 (50)

2.48 (1.99–3.09)

 

Arrhythmia

 No

439 (35)

807 (65)

1

 

 Yes

101 (66)

51 (34)

3.64 (2.55–5.20)

< 0.001

Documented cirrhosis

 No

496 (38)

811 (62)

1

 

 Yes

44 (48)

47 (52)

1.53 (1.00–2.34)

0.050

Congestive cardiac failure

 No

506 (37)

852 (63)

1

< 0.001

 Yes

34 (85)

6 (15)

9.54 (3.98–22.88)

 

Diabetic status

 Negative

400 (39)

634 (61)

1

0.300

 Non-insulin

123 (40)

183 (60)

1.07 (0.82–1.38)

0.634

 Insulin dependent

17 (29)

41 (71)

0.66 (0.37–1.17)

0.155

COPD

 No

247 (29)

619 (71)

1

< 0.001

 Yes

293 (55)

243 (45)

3.02 (2.40–3.76)

 

Previous cardiac event

 No

302 (31)

673 (69)

1

< 0.001

 Yes

238 (56)

185 (44)

2.87 (2.27–3.63)

 

Prior TIA/stroke

 No

446 (35)

823 (65)

1

< 0.001

 Yes

94 (73)

35 (27)

4.96 (3.31–7.43)

 

Chronic renal impairment

 No

323 (28)

824 (72)

1

< 0.001

 Yes

217 (86)

34 (14)

16.28 (11.09–23.90)

 

Number of procedures

 1

252 (32)

530 (68)

1

< 0.001

 ≥ 2

288 (47)

328 (53)

1.85 (1.48–2.30)

 

Cancer stage

 Primary

474 (38)

760 (62)

1

< 0.001

 Local nodal metastases

45 (32)

95 (68)

0.76 (0.52–1.10)

0.148

 Distant metastases

20 (87)

3 (13)

10.69 (3.16–36.17)

< 0.001

Surgical categories

 Hepatobiliary

85 (37)

143 (63)

  

 Urology

141 (41)

199 (59)

  

 General surgery

129 (39)

201 (61)

  

 Colorectal/lower GI

30 (25)

88 (75)

  

 Upper GI

99 (42)

135 (58)

  

 Gynaecological

52 (38)

86 (62)

  

 Sarcoma

3 (33)

6 (67)