Table 2 Population characteristics and surgical factors according to NSAID use
Flurbiprofen (n=2282) | No NSAIDs (n=1371) | P value | |
|---|---|---|---|
Age | 61 (53–67) | 61 (54–68) | 0.2759 |
Sex, n (%) | 0.03 | ||
Male | 1524 (66.78%) | 963 (70.24%) | |
Female | 758 (33.22%) | 408 (29.76%) | |
BMI | 23 (20.9–25) | 23 (20.9–25.1) | 0.7447 |
Tobacco use | 0.3813 | ||
Non-smoker | 952 (60.33%) | 580 (59.67%) | |
Previous smoker | 514 (22.57%) | 328 (33.74%) | |
Active smoker | 112 (7.10%) | 64 (6.58%) | |
Alcohol | 0.7876 | ||
Non-drinker | 1123 (71.44%) | 699 (71.99%) | |
Previous drinker | 386 (24.55 %) | 227 (23.38%) | |
Active drinker | 63 (4.01%) | 45 (4.63%) | |
Ischemic heart disease | 93 (4.08%) | 36 (2.63%) | 0.0215 |
Hypertension | 481 (21.08%) | 276 (20.13%) | 0.4943 |
Diabetes | 213(9.93%) | 125 (9.12%) | 0.8269 |
Respiratory system disease | 19 (0.83%) | 12 (0.88%) | 0.8917 |
ASA score | 0.7537 | ||
1 | 44 (1.93%) | 22 (1.61%) | |
2 | 1964 (86.10%) | 1196 (87.3%) | |
3 | 264 (11.57%) | 147 (10.73%) | |
4 | 9 (0.39%) | 5 (0.36%) | |
Tumor stage | 0.4766 | ||
1 | 574 (25.15%) | 373 (27.21%) | |
2 | 717 (31.42%) | 421 (30.71%) | |
3 | 972 (42.59%) | 569 (41.50%) | |
4 | 19 (0.83%) | 8 (0.58%) | |
Procedure type | <.0001 | ||
Gastrectomy | 1222 (53.55%) | 832 (60.69%) | |
Colorectomy | 1060 (46.45%) | 539 (39.31%) | |
Procedure approach | <.0001 | ||
Laparoscopic | 1256 (55.04%) | 452 (33.09%) | |
Open | 1026 (44.96%) | 919 (66.91%) | |
Intraoperative blood loss (ml) | 100 (50–150) | 100 (50–200) | <.0001 |
Intraoperative transfusion (yes) | 140 (6.13%) | 109 (7.95%) | 0.035 |
Operating duration | 3 (2.42–3.83) | 3 (2.42–3.75) | 0.809 |
Anastomotic leakage | 37 (1.62%) | 20 (1.46%) | 0.701 |
In-hospital mortality | 1 (0.04%) | 1 (0.07%) | 0.7156 |