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Table 2 Population characteristics and surgical factors according to NSAID use

From: Postoperative short-term use of the nonsteroidal anti-inflammatory drug flurbiprofen did not increase the anastomotic leakage rate in patients undergoing elective gastrointestinal surgery—a retrospective cohort study

  Flurbiprofen (n=2282) No NSAIDs (n=1371) P value
Age 61 (53–67) 61 (54–68) 0.2759
Sex, n (%)    0.03
 Male 1524 (66.78%) 963 (70.24%)  
 Female 758 (33.22%) 408 (29.76%)  
BMI 23 (20.9–25) 23 (20.9–25.1) 0.7447
Tobacco use    0.3813
 Non-smoker 952 (60.33%) 580 (59.67%)  
 Previous smoker 514 (22.57%) 328 (33.74%)  
 Active smoker 112 (7.10%) 64 (6.58%)  
Alcohol    0.7876
 Non-drinker 1123 (71.44%) 699 (71.99%)  
 Previous drinker 386 (24.55 %) 227 (23.38%)  
 Active drinker 63 (4.01%) 45 (4.63%)  
Ischemic heart disease 93 (4.08%) 36 (2.63%) 0.0215
Hypertension 481 (21.08%) 276 (20.13%) 0.4943
Diabetes 213(9.93%) 125 (9.12%) 0.8269
Respiratory system disease 19 (0.83%) 12 (0.88%) 0.8917
ASA score    0.7537
 1 44 (1.93%) 22 (1.61%)  
 2 1964 (86.10%) 1196 (87.3%)  
 3 264 (11.57%) 147 (10.73%)  
 4 9 (0.39%) 5 (0.36%)  
Tumor stage    0.4766
 1 574 (25.15%) 373 (27.21%)  
 2 717 (31.42%) 421 (30.71%)  
 3 972 (42.59%) 569 (41.50%)  
 4 19 (0.83%) 8 (0.58%)  
Procedure type    <.0001
 Gastrectomy 1222 (53.55%) 832 (60.69%)  
 Colorectomy 1060 (46.45%) 539 (39.31%)  
Procedure approach    <.0001
 Laparoscopic 1256 (55.04%) 452 (33.09%)  
 Open 1026 (44.96%) 919 (66.91%)  
Intraoperative blood loss (ml) 100 (50–150) 100 (50–200) <.0001
Intraoperative transfusion (yes) 140 (6.13%) 109 (7.95%) 0.035
Operating duration 3 (2.42–3.83) 3 (2.42–3.75) 0.809
Anastomotic leakage 37 (1.62%) 20 (1.46%) 0.701
In-hospital mortality 1 (0.04%) 1 (0.07%) 0.7156
  1. BMI body mass index, ASA American Society of Anesthesiologists