Normoxia/near-normoxia (n = 229) | Mild hyperoxia (n = 991) | Severe hyperoxia (n = 173) | P | |
---|---|---|---|---|
Demographic data | ||||
Age (y) | 70 (63–75) | 67 (60–73) | 67 (58–73) | 0.007 |
Female | 61 (26.6%) | 227 (22.9%) | 35 (20.2%) | 0.298 |
Body mass index (kg/m2) | 25.4 (23.2–27.8) | 24.0 (22.0–26.2) | 23.1 (20.8–25.2) | < 0.001 |
Smoker | 65 (28.4%) | 311 (31.4%) | 60 (34.7%) | 0.401 |
Medical history | ||||
Hypertension | 164 (71.6%) | 614 (62.0%) | 91 (52.6%) | <0.001 |
Diabetes on insulin | 33 (14.4%) | 135 (13.6%) | 21 (12.1%) | 0.802 |
Dyslipidaemia | 72 (31.4%) | 267 (26.9%) | 39 (22.5%) | 0.135 |
Atrial fibrillation | 16 (7.0%) | 58 (5.9%) | 10 (5.8%) | 0.801 |
Recent myocardial infarctiona | 48 (21.0%) | 148 (14.9%) | 20 (11.6%) | 0.023 |
Congestive heart failure | 17 (7.4%) | 56 (5.7%) | 16 (9.2%) | 0.159 |
Chronic lung disease | 15 (6.6%) | 38 (3.8%) | 7 (4.0%) | 0.186 |
Extracardiac arteriopathy | 46 (20.1%) | 181 (18.3%) | 33 (19.1%) | 0.807 |
Cerebrovascular disease | 57 (24.9%) | 225 (22.7%) | 35 (20.2%) | 0.543 |
Previous cardiac surgery | 3 (1.3%) | 24 (2.4%) | 2 (1.2%) | 0.376 |
Preoperative clinical data | ||||
Left ventricular systolic function | 0.536 | |||
Normal (EF > 50%) | 155 (67.7%) | 729 (73.6%) | 122 (70.5%) | |
Moderate (EF 31–50%) | 54 (23.6%) | 198 (20.0%) | 38 (22.0%) | |
Poor (EF 21–30%) | 18 (7.9%) | 52 (5.2%) | 10 (5.8%) | |
Very poor (EF ≤ 20%) | 2 (0.9%) | 12 (1.2%) | 3 (1.7%) | |
Pulmonary hypertensionb | 41 (17.9%) | 113 (11.4%) | 15 (8.7%) | 0.008 |
Left main coronary artery disease | 62 (27.1%) | 254 (25.6%) | 37 (21.4%) | 0.399 |
Renal impairmentc | 0.444 | |||
Normal (CC > 85 mL/min) | 57 (24.9%) | 245 (24.7%) | 38 (22.0%) | |
Moderate (CC 50–85 mL/min) | 108 (47.2%) | 485 (48.9%) | 82 (47.4%) | |
Severe (CC < 50 mL/min) | 47 (20.5%) | 191 (19.3%) | 32 (18.5%) | |
On dialysis regardless of CC | 17 (7.4%) | 70 (7.1%) | 21 (12.1%) | |
Haematocrit (%) | 38 (5) | 38 (4) | 37 (4) | 0.186 |
Surgery profile | ||||
Emergency | 18 (7.9%) | 38 (3.8%) | 4 (2.3%) | 0.010 |
No. of coronary artery anastomoses | 3 (3–4) | 4 (3–4) | 3 (3–4) | 0.368 |
Duration of surgery (min) | 365 (317–400) | 360 (325–395) | 325 (295–370) | < 0.001 |