Effect of sedative premedication with oral midazolam on postanesthesia care unit delirium in older adults: a secondary analysis following an uncontrolled before-after design

Table 4 Subgroup analysis

	OR	95% CI	P
First step
Midazolam (reference: no midazolam)	0.805	0.140; 4.620	0.808
Year of enrollment (per year increase)	0.823	0.438; 1.566	0.563
ORP (reference: RARP)	1.163	0.595; 2.169	0.700
Age (per year increase)	1.103	1.044; 1.164	< 0.001
ASA physical status (reference: ASA III)
ASA I	0.872	0.435; 1.748	0.699
ASA II	1.140	0.468; 2.776	0.772
Estimated blood loss (per ml increase)	1.093	0.752; 1.588	0.642
Duration of surgery (per min increase)	2.661	0.668; 10.597	0.165
Sufentanil (per μg kg⁻¹ h⁻¹ increase)	1.010	0.996; 1.024	0.145
Final step
Midazolam (reference: no midazolam)	1.240	0.241; 6.386	0.797
Year of enrollment (per year increase)	0.933	0.513; 1.695	0.819
Age (per year increase)	1.100	1.043; 1.161	< 0.001
Duration of surgery (per min increase)	4.123	1.284; 13.241	0.017

Subgroup analysis of 337 patients who received sevoflurane for anesthesia maintenance with postanesthesia care unit delirium as the dependent variable. ‘Midazolam’ and ‘year of enrollment’ were forced into the model. ‘Duration of surgery’ and ‘estimated blood loss’ were transformed to their binary logarithm (ln(x)/ln(2)). RARP robot-assisted radical prostatectomy. ORP open retropubic radical prostatectomy

ISSN: 2047-0525