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Table 3 Days at Home within 90 days after surgery (DAH-90). Association between the DAH-90, a patient centric measure, and continuous or dichotomised preoperative variables, including the Charlson Co-morbidity score, laboratory biomarkers and CPET-derived variables. Analysis was done using linear regression analysis

From: Clinical covariates that improve surgical risk prediction and guide targeted prehabilitation: an exploratory, retrospective cohort study of major colorectal cancer surgery patients evaluated with preoperative cardiopulmonary exercise testing

Preoperative parameters Dichotomised reference level N beta 95%CI P-value
A. Univariable analysis
Charlson Co-morbidity Index
  i. Continuous   80 − 0.86 − 2.59, 0.86 0.330
  ii. Dichotomised < 5 80 − 4.47 − 12.10, 3.14 0.250
Laboratory parameters
  i. Continuous
   • Haemoglobin (g/l)   58 0.24 − 0.01, 0.49 0.060
   • White cell count (× 109/l)   58 − 1.94 − 3.67, − 0.21 0.028
   • Neutrophils (× 109/l)   58 − 2.59 − 4.63, − 0.55 0.013
   • Albumin (g/l)   34 1.37 0.57, 2.17 0.001
   • Modified (neutrophil-albumin) Glasgow Prognostic Score   34 − 12.50 − 19.40, − 5.48 < 0.001
  ii. Dichotomised Risk cut-point     
   • Haemoglobin (g/l) < 110 58 10.6 0.09, 21.00 0.048
   • White Cell Count (× 109/l > 11 58 − 26.50 − 43.40, − 9.55 0.002
   • Neutrophils (× 109/l > 7.5 58 − 26.90 − 41.80, − 11.90 < 0.001
   • Platelets (× 109/l > 350 58 − 6.27 − 19.60, 7.07 0.360
   • Albumin (g/l) < 35 34 10.3 0.02, 20.60 0.050
  iii. Ratios
Neutrophil-lymphocyte ratio (NLR) > 4 58 − 0.32 − 9.96, 9.33 0.950
Platelet-lymphocyte ratio (PLR) > 160 58 − 2.76 − 12.70, 7.24 0.590
CPET-derived parameters
  i. Continuous
   • Peak VO2 (ml/kg/min)   80 0.62 − 0.15, 1.39 0.110
   • Peak VO2 (ml/min/m2) (× 100)   80 2.07 0.12, 4.01 0.038
   • VO2 @ AT (ml/kg/min)   80 0.45 − 0.81, 1.71 0.490
   • Ve/VCO2 @ AT   80 − 0.56 − 1.21, 0.08 0.088
   • PETCO2 @ AT (mmHg)   80 0.68 0.05, 1.31 0.033
  ii. Dichotomised Risk cut-point     
   • Peak VO2 (ml/kg/min) ≤ 16 80 10.60 3.00, 18.20 0.006
   • Peak VO2 (ml/min/m2) < 710 80 9.46 2.08, 16.90 0.012
   • VO2 @ AT (ml/kg/min) < 12 80 1.94 − 5.88, 9.75 0.630
   • Ve/VCO2 @ AT > 35 80 − 13.3 − 23.7, − 3.01 0.011
   • PETCO2 @ AT (mmHg) < 35 80 11.20 − 0.08, 22.60 0.052
B. Bi-variable analysis
 • Peak VO2 (ml/kg/min) ≤ 16 51 19.00 11.00, 27.00 < 0.001
 • Modified (neutrophils-albumin) Glasgow Prognostic Score − 10.00 − 16.00, − 4.50 < 0.001
  1. CPET, cardiopulmonary exercise testing; Peak VO2, maximum rate of oxygen consumption measured during incremental exercise; VO2 @ AT, oxygen uptake at anaerobic threshold; Ve/VCO2, minute ventilation relative to carbon dioxide elimination; PETCO2 @ AT, partial pressure of end tidal carbon dioxide at anaerobic threshold