Table 1 Included studies characteristics, intervention and control groups extracted, primary study outcome and pain outcomes reported
Study 1st author year | Country | Procedures | Participants included, no | Participant characteristics | Intervention(s) and control(s) | Primary outcome(s) | Pain outcome(s) reported |
|---|---|---|---|---|---|---|---|
Alghanem 2010 (Alghanem et al., 2010) | Jordan | Laparoscopic cholecystectomy | 180 | ASA ≤ 2 Age 18–70 Mix M/F | I: Intraoperative dexamethasone 8 mg IV C: Ondansetron or saline | PONV | Pain scores |
Areeruk 2016 (Areeruk et al., 2016) | Thailand | Gynaecological laparotomy via pfannenstiel incision | 49 | ASA ≤ 2 Age 18-65 | I: Intraoperative dexamethasone 8 mg IV C: Saline | Total morphine consumption | Pain scores Opioid consumption |
Badawy 2015 (Badawy & Sakka, 2015) | Egypt | Total abdominal hysterectomy | 38 | ASA ≤2 Age 40–70 | I: Preoperative dexamethasone 8 mg IV + gabapentin 800 mg PO C: Saline + gabapentin | Time to first analgesia | Pain scores Time to first analgesia Opioid consumption |
Bataille 2016 (Bataille et al., 2016) | France | Laparoscopic sleeve gastrectomy | 117 | ASA ≤ 3 Age 18–75 BMI >40 ≥ 2 RFs PONV Mix M/F | I: Intraoperative dexamethasone 4 mg + ondansetron 4 mg IV C: Saline | PONV | Pain scores |
Batistaki 2019 (Batistaki et al., 2019) | Greece | Laparoscopic cholecystectomy | 44 | ASA ≤ 3 Age 18–75 Predominantly female | I: Intraoperative dexamethasone 5 mg C: Saline | Reversal NMB | Pain scores |
Benevides 2013 (Benevides et al., 2013) | Brazil | Laparoscopic sleeve gastrectomy | 60 | ASA 1–3 Age 18+ BMI ≥ 35 | I: Intraoperative dexamethasone 8 mg + ondansetron 8 mg IV C: Saline + ondansetron | PONV Rescue antiemetic use | Opioid consumption PACU LOS |
Bianchin 2007 (Bianchin et al., 2007) | Italy | Laparoscopic cholecystectomy | 73 | ASA ≤ 2 Predominantly female | I: Preoperative dexamethasone 8 mg IV C: Saline | PONV | Pain scores |
Biligin 2010 (Bilgin et al., 2010) | Turkey | Total abdominal hysterectomy + bilateral salpingoophorectomy | 160 | ASA ≤ 2 Age 20-60 | I: Preoperative dexamethasone 8 mg IV C: Saline or ondansetron or metoclopramide | PONV | Pain scores |
Bisgaard 2003 (Bisgaard et al., 2003) | Denmark | Laparoscopic cholecystectomy | 80 | ASA ≤ 2 Age < 75 Predominantly female | I: Preoperative dexamethasone 8 mg IV C: Saline | Pain Fatigue | Pain Scores Opioid consumption PACU LOS |
Coloma 2002 (Coloma et al., 2002) | USA | Laparoscopic cholecystectomy | 140 | ASA ≤ 2 Predominantly female | I: Intraoperative dexamethasone 4 mg IV C: Saline | Recovery times | Time to first analgesia Opioid consumption PACU LOS |
Corcoran 2017 (Corcoran et al., 2017) | Australia | Major laparoscopic gynaecological surgery | 31 | ASA ≤ 2 Age 18–60 Surgery > 90 min ≥ 1-night stay | I: Intraoperative dexamethasone 4 mg IV C: Saline | Immune response | Pain scores |
De Oliveira 2011 (De Oliveira Jr. et al., 2011b) | USA | Laparoscopic gyanecological surgery | 106 | ASA ≤ 2 | I: Preoperative dexamethasone 0.05 or 0.1 mg kg−1 IV C: Saline | QoR-40 | Pain scores Time to first analgesia Opioid consumption |
Elhakim 2002 (Elhakim et al., 2002) | Egypt | Laparoscopic cholecystectomy | 180 | Predominantly male | I: Preoperative dexamethasone 2 or 4 or 8 or 16 mg IV C: Saline or ondansetron | PONV | Pain scores Time to first analgesia Opioid consumption |
Feo 2006 (Feo et al., 2006) | Italy | Laparoscopic cholecystectomy | 101 | ASA ≤ 3 F>M | I: Preoperative dexamethasone 8mg IV C: Saline | Pain PONV Analgesic and antiemetic requirements | Pain scores |
Fukami 2009 (Fukami et al., 2009) | Japan | Laparoscopic cholecystectomy | 80 | Mix M/F | I: Preoperative dexamethasone 8 mg IV C: Saline | PONV Pain Fatigue Analgesic and antiemetic requirements | Pain scores |
Gautam 2008 (Gautam et al., 2008) | Nepal | Laparoscopic cholecystectomy | 142 | ASA ≤ 2 Age 23–65 | I: Preoperative dexamethasone 8 mg IV or dexamethasone 8 mg IV + ondansetron 4 mg C: Ondansetron | PONV | Pain scores Time to first analgesia Opioid consumption |
Hammas 2002 (Hammas et al., 2002) | Sweden | Cholecystectomy, Inguinal hernia repair | 76 | ASA ≤ 2 Predominantly male | I: Intraoperative dexamethasone 4 mg + ondansetron 4 mg + droperidol 1.25 mg + metoclopramide 10 mg IV C: Propofol infusion | PONV | Opioid consumption |
Ionescu 2014 (Ionescu et al., 2014) | Romania | Laparoscopic cholecystectomy | 42 | ASA ≤ 2 Predominantly female | I: Preoperative dexamethasone 4 mg IV C: Saline | Immune response | Opioid consumption |
Jo 2012 (Jo et al., 2012) | Korea | Laparoscopic cholecystectomy | 120 | ASA ≤ 2 Female Age 21–64 BMI < 35 | I: Preoperative dexamethasone 8mg IV + saline intraoperative or preoperative dexamethasone 8mg IV + ramosetron 0.3 mg IV intraoperative C: Saline + ramosetron | PONV | Pain scores |
Jokela 2009 (Jokela et al., 2009) | Finland | Laparoscopic hysterectomy +/- oophorectomy | 120 | ASA ≤ 3 BMI < 35 | I: Preoperative dexamethasone 5 or 10 or 15mg IV C: Saline | Pain Opioid consumption | Pain scores Time to first analgesia Opioid consumption |
Kasagi 2013 (Kasagi et al., 2013) | Japan | Hysterectomy, cystectomy, myomectomy | 60 | ASA ≤ 2 Age 20–-50 Benign disease | I: Preoperative dexamethasone 8 mg IV C: Droperidol | PONV | Pain scores |
Kassim 2018 (Kassim et al., 2018) | Egypt | Laparoscopic gyanecological surgery for infertility | 50 | ASA ≤ 2 Age 25–35 | I: Preoperative dexamethasone 0.1 mg kg−1 IV + duloxetine 60 mg PO C: Saline + duloxetine | Pethidine requirements | Pain scores Time to first analgesia Opioid consumption |
Ko-iam 2015 (Ko-Iam et al., 2015) | Thailand | Laparoscopic cholecystectomy | 100 | ASA ≤ 2 Age 18–75 Predominantly female | I: Intraoperative dexamethasone 8 mg + metoclopramide 10 mg IV C: Metoclopramide | PONV | Pain scores Opioid consumption |
Kurz 2015 (Kurz et al., 2015) | USA | Colorectal resection | 555 | Age ≤ 80 Surgery 2–6 h | I: Intraoperative dexamethasone 4 mg IV & 30% oxygen or intraoperative dexamethasone 4 mg IV & 80% oxygen C: Saline + oxygen | Surgical site infection | Pain scores |
Lee 2017 (Lee et al., 2017) | Republic of Korea | Laparoscopic cholecystectomy | 380 | ASA ≤ 2 Age 18–45 Mix M/F | I: Preoperative dexamethasone 5 mg IV C: Saline | Morphine requirements | Pain scores Time to first analgesia Opioid consumption |
Lim 2011 (Lim et al., 2011) | Korea | Laparoscopic cholecystectomy | 120 | ASA ≤ 2 M>F | I: Preoperative dexamethasone 8 mg + intraoperative saline or preoperative saline + intraoperative dexamethasone 8 mg IV C: Saline | Pain | Pain scores Opioid consumption |
Liu 1998 (Liu et al., 1998) | Taiwan | Major gynaecological surgery | 60 | ASA ≤ 2 | I: Intraoperative dexamethasone 10 mg C: Saline | PONV Pain | Pain scores Opioid consumption |
Liu 1999 (Liu et al., 1999) | Taiwan | Abdominal and radical hysterectomy, myomectomy | 150 | ASA ≤ 2 | I: Preoperative dexamethasone 1.25 or 2.5 or 5 or 10 mg IV C: Saline | PONV | Pain scores Time to first analgesia Opioid consumption |
Lopez-Olaondo 1996 (Lopez-Olaondo et al., 1996) | Spain | Major abdominal gynaecological surgery | 100 | ASA ≤ 2 Age 18–65 45–90 kg | I: Preoperative dexamethasone 8 mg + ondansetron 4 mg IV C: Saline + ondansetron | PONV | Pain scores Opioid consumption |
Maddali 2003 (Maddali et al., 2003) | Oman | Laparoscopic gyanecological surgery | 120 | ASA ≤ 2 Age ≤ 60 | I: Preoperative dexamethasone 8 mg + ondansetron 4 mg IV or dexamethasone 8mg + metoclopramide 10 mg C: Saline | PONV | Pain scores |
Mathiesen 2009 (Mathiesen et al., 2009) | Denmark | Abdominal hysterectomy +/- salpingoophorectomy | 76 | ASA ≤ 2 Age 18–75 BMI 18–32 | I: Preoperative dexamethasone 8 mg IV+ paracetamol 1g PO+ pregabalin 300 mg PO C: Saline + paracetamol + gabapentin | Morphine consumption | Pain scores Opioid consumption |
McKenzie 1997 (McKenzie et al., 1997) | USA | Abdominal or vaginal hysterectomy, laparotomy, anterior and posterior repair | 80 | ASA ≤ 3 Age 18–65 | I: Intraoperative dexamethasone 20 mg IV + ondansetron 4 mg IV C: Saline + ondansetron | PONV | Pain scores Opioid consumption |
Murphy 2011 (Murphy et al., 2011) | USA | Laparoscopic cholecystectomy | 115 | ASA ≤ 3 F>M | I: Preoperative dexamethasone 8 mg IV C: Saline | QoR-40 | Pain scores Opioid consumption PACU LOS |
Murphy 2014 (Murphy et al., 2014) | USA | Laparoscopic or open hysterectomy | 195 | ASA ≤ 3 Age 18–80 | I: Intraoperative dexamethasone 4 or 8 mg IV C: Saline | Perioperative glucose concentration | Pain scores Opioid consumption PACU LOS |
Nesek-Adam 2007 (Nesek-Adam et al., 2007) | Croatia | Laparoscopic cholecystectomy | 160 | ASA ≤ 2 Predominantly female | I: Intraoperative dexamethasone 8 mg IV + saline or dexamethasone 8 mg + metoclopramide 10 mg C: Saline or saline + metoclopramide | PONV | Pain scores Time to first analgesia |
Olajumoke 2013 (Olajumoke et al., 2013) | Nigeria | Total abdominal hysterectomy, myomectomy | 96 | ASA ≤ 2 Age 18–65 | I: Intraoperative dexamethasone 4 mg IV C: Saline | PONV | PACU LOS |
Pan 2008 (Pan et al., 2008) | USA | Laparoscopic gynaecological surgery | 60 | ASA ≤ 2 Age ≥18 ≥ 3 emetic risk factors | I: Intraoperative dexamethasone 8 mg + ondansetron 4 mg IV + ondansetron PO D0,1,2 C: Saline + ondansetron | PONV | Pain scores Opioid consumption PACU LOS |
Pauls 2015 (Pauls et al., 2015) | USA | Major vaginal reconstructive surgery | 63 | ASA ≤ 3 | I: Preoperative dexamethasone 8 mg IV C: Saline | Quality of recovery | Pain scores Opioid consumption |
Regasa 2020 (Regasa et al., 2020) | Ethiopia | Major gynaecological surgery | 96 | ASA ≤ 2 Age 18–65 | I: Intraoperative dexamethasone 8 mg IV + saline or dexamethasone 8 mg + metoclopramide 10 mg C: metoclopramide | PONV | Opioid consumption |
Rothenberg 1998 (Rothenberg et al., 1998) | USA | Laparoscopic gynaecological surgery | 95 | ASA ≤ 2 | I: Intraoperative dexamethasone 0.17 mg kg−1 IV C: Droperidol | PONV | Pain scores Opioid consumption PACU LOS |
Ryu 2013 (Ryu et al., 2013) | Korea | Laparoscopic cholecystectomy | 72 | ASA ≤ 2 Age 25–65 | I: Intraoperative dexamethasone 8 mg + ramosetron 0.3 mg IV C: Saline + ramosetron | PONV | Pain scores |
Sanchez-Ledesma 2002 (Sanchez-Ledesma et al., 2002) | Spain | Hysterectomy, myomectomy/adnexectomy, oncological gynaecological reduction | 90 | ASA ≤ 2 Age 18–65 45–90 kg | I: Intraoperative dexamethasone 8 mg + droperidol 1.25 mg IV + postoperative droperidol or dexamethasone 8 mg + ondansetron 4 mg and postoperative saline C: Ondansetron + droperidol | PONV | Pain scores Opioid consumption |
Sanchez-Rodriquez 2010 (Sanchez-Rodriguez et al., 2010) | Mexico | Laparoscopic cholecystectomy | 210 | ASA ≤ 2 Age ≤ 80 F>M | I: Preoperative dexamethasone 8 mg IV C: Placebo | PONV Pain Fatigue Additional analgesic and antiemetic drugs | Pain scores |
Shrestha 2014 (Shrestha et al., 2014) | Nepal | Laparoscopic cholecystectomy | 120 | ASA ≤ 2 Age 17–75 Predominantly female | I: Preoperative dexamethasone 8 mg + pheniramine 45.5 mg IV C: Saline | Pain Systemic acute phase response | Pain scores |
Sistla 2009 (Sistla et al., 2009) | India | Laparoscopic cholecystectomy | 70 | Predominantly female | I: Preoperative dexamethasone 8 mg IV C: Saline | Morphine consumption | Pain scores Opioid consumption |
Thangaswamy 2010 (Thangaswamy et al., 2010) | India | Total laparoscopic hysterectomy | 55 | ASA ≤ 2 Age 18–60 | I: Preoperative dexamethasone 4 or 8 mg IV C: Saline | Fentanyl consumption | Pain scores Time to first analgesia Opioid consumption |
Tolver 2012 (Tolver et al., 2012) | Denmark | Transabdominal preperitoneal groin repair | 73 | ASA ≤ 2 Age 18–5 | I: Preoperative dexamethasone 8 mg IV C: Saline | Pain | Pain scores Opioid consumption |
Viriyaroj 2015 (Viriyaroj et al., 2015) | Thailand | Laparoscopic cholecystectomy | 80 | Predominantly female | I: Preoperative dexamethasone 8 mg IV C: Saline | Pain Analgesic consumption | Pain scores Opioid consumption |
Wang 1999 (Wang et al., 1999) | Taiwan | Laparoscopic cholecystectomy | 78 | ASA ≤ 2 Age 30–55 Predominantly female | I: Preoperative dexamethasone 8 mg IV C: Saline | PONV | Pain scores Opioid consumption |
Wang 2000 (Wang et al., 2000) | Taiwan | Total abdominal hysterectomy | 120 | ASA ≤ 2 Age 35-45 | I: Preoperative dexamethasone 10 mg IV + postoperative saline or preoperative saline + postoperative dexamethasone 10 mg IV C: Saline | PONV | Pain scores Opioid consumption |
Wu 2009 (Wu et al., 2009) | Taiwan | Anorectal surgery | 60 | ASA ≤ 2 Predominantly female | I: Preoperative dexamethasone 5 mg IV C: Saline | PONV | Pain scores Opioid consumption |
Yuksek 2003 (Yuksek et al., 2003) | Turkey | Laparoscopic gyanecological surgery | 60 | ASA ≤ 2 19–62 | I: Preoperative dexamethasone 8 mg IV C: Saline or ondansetron | PONV | Pain scores Time to first analgesia |