Disadvantages of using honey | Limitations of the study |
---|---|
High price | The effects of various types of honey and their concentration were not studied yet |
Becomes more fluid at high temperatures, and it may liquefy at ambient wound temperature, and risk of leakage | Some of the patients in intervention and placebo groups were lost to follow-up, and replaced with the other ones. |
Risk of liquefaction restricts body site usage | The PSD tissue was not evaluated by the computed tomography (CT) scan or magnetic resonance imaging (MRI). |
Due to bacterial inoculation of the wound from unsterilized honey, sterilization of unprocessed honey is needed | For the widespread use of honey, appropriate sterilization on unprocessed honey is needed (i.e., gamma-irradiated), and in this study we could not apply that |
Could cause pain and discomfort | Â |
Gamma-irradiated for sterilization of unprocessed honey is expensive | Â |