Disadvantages of using honey
Limitations of the study
The effects of various types of honey and their concentration were not studied yet
Becomes more fluid at high temperatures, and it may liquefy at ambient wound temperature, and risk of leakage
Some of the patients in intervention and placebo groups were lost to follow-up, and replaced with the other ones.
Risk of liquefaction restricts body site usage
The PSD tissue was not evaluated by the computed tomography (CT) scan or magnetic resonance imaging (MRI).
Due to bacterial inoculation of the wound from unsterilized honey, sterilization of unprocessed honey is needed
For the widespread use of honey, appropriate sterilization on unprocessed honey is needed (i.e., gamma-irradiated), and in this study we could not apply that
Could cause pain and discomfort
Gamma-irradiated for sterilization of unprocessed honey is expensive