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Table 3 Perioperative kidney function

From: Impact on grafted kidney function of rocuronium-sugammadex vs cisatracurium-neostigmine strategy for neuromuscular block management. An Italian single-center, 2014-2017 retrospective cohort case-control study

Variable

Baseline

D0

D1

D2

D3

D4

D5

Creatinine (μmol/L) [IQR]

 

 NEO

753.0 [614.5-993.5]

639.0 [527.7-870.0]

558.0 [365.5-720.5]

397.0 [202.5-643.5]

253.0 [137.5-555.5]

190.0 [121.5-439.5]

170.0 [115.0-430.5]

 SUG

759.0 [585.5-948.5]

596.0 [478.0-749.0] *

504.0 [370.0-658.0]

384.0 [170.0-596.5]

214.0 [126.5-496.5]

183.0 [117.0-433.5]

162.0 [107.5-379.0]

Creatinine (μmol/L) [IQR]

 SUG < 4 mg/kg (101 pts)

757.0 [592.0-944.0]

605.0 [502.0-744.0]

484.0 [367.0-642.0]

360.0 [170.0-611.0]

228.0 [134.0-500.0]

185.0 [126.0-437.0]

168.0 [121.0-399.0]

 SUG ≥ 4 mg/kg (74 pts)

763.5 [573.0-953.0]

564.5 [461.5-798.5]

511.5 [378.5-680.5]

400.5 [173.5-569.0]

208.0 [119.7-494.0]

169.0 [104.7-422.0]

155.0 [100.0-362.0]

Urea (mmol/L) [IQR]

 NEO

18.7 [13.85-24.95]

17.1 [13.1-22.0]

17.5 [13.5-21.8]

17.9 [12.4-24.9]

16.4 [10.4-25.4]

15.8 [9.9-27.6]

14.7 [9.6-25.3]

 SUG

17.6 [13.62-23.6]

14.9 [10.8-21.6] *

15.3 [11.3-19.8] *

15.9 [8.8-20.5] *

14.9 [7.5-20.7] *

14.2 [7.7-23.0]

12.9 [7.7-24.7]

Urea (mmol/L) [IQR]

 SUG < 4 mg/kg (101 pts)

17.44 [13.93-24.09]

15.48 [11.96-22.82]

15.9 [11.5-19.7]

16.4 [10.0-20.6]

14.7 [8-20.8]

14.4 [8.45-22.8]

14.37 [8.2-23.9]

 SUG ≥ 4 mg/kg (74 pts)

17.6 [12.5-23.42]

14.3 [10.3-20.64]

14.45 [11.0-19.8]

14.7 [7.45-20.47]

15.1 [6.69-20.7]

13.35 [7.12-23.32]

12.5 [7.2-25.5]

eGFR [IQR]

 NEO

6.0 [5.0-8.0]

8.0 [6.0-10.0]

9.0 [7.0-14.0]

13.0 [7.5-29.0]

21.0 [9.0-43.5]

31.0 [11.0-51.0]

35.0 [12.2-53.7]

 SUG

6.0 [5.0-8.0]

8.0 [6.0-11.0] *

10.0 [7.0-14.5]

14.0 [8.0-36.0]

23.0 [10.0-52.5]

32.0 [12.0-59.5]

36.0 [14.0-61.0]

eGFR [IQR]

 SUG < 4 mg/kg (101 pts)

6.0 [5.0-8.0]

8.0 [6.0-11.0]

10.0 [7.0-15.0]

15.0 [8.0-38.0]

23.0 [10.0-52.0]

32.0 [13.0-55.0]

36.0 [14.0-56.0]

 SUG ≥ 4 mg/kg (74 pts)

6.0 [5.0-8.0]

8.0 [6.0-10.0]

9.0 [6.0-12.75]

14.0 [8.0-33.75]

26.0 [10.0-54.0]

33.0 [12.0-63.75]

37.0 [15.0-64.0]

  1. NMB neuromuscular block, NEO group of patients receiving neostigmine for reversal of cisatracurium-induced NMB, SUG group of patients receiving sugammadex for reversal of rocuronium-induced NMB, SUG <4 mg/kg and SUG ≥4 mg/kg sugammadex dose per kg of body weight for reversal of moderate or deep NMB, respectively, baseline value before kidney transplantation, DO-D5 values obtained the day of kidney transplantation (D0) and in each of the following five postoperative days (D1-D5), eGRF estimated glomerular filtration rate, creatinine and urea serum creatinine and serum urea, eGRF estimated glomerular filtration rate. Data are expressed as median [interquartile range, IQR]. (*) = significant p value (< 0.05) at intergroups analysis
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Perioperative Medicine

ISSN: 2047-0525