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Table 3 Perioperative kidney function

From: Impact on grafted kidney function of rocuronium-sugammadex vs cisatracurium-neostigmine strategy for neuromuscular block management. An Italian single-center, 2014-2017 retrospective cohort case-control study

Variable Baseline D0 D1 D2 D3 D4 D5
Creatinine (μmol/L) [IQR]  
 NEO 753.0 [614.5-993.5] 639.0 [527.7-870.0] 558.0 [365.5-720.5] 397.0 [202.5-643.5] 253.0 [137.5-555.5] 190.0 [121.5-439.5] 170.0 [115.0-430.5]
 SUG 759.0 [585.5-948.5] 596.0 [478.0-749.0] * 504.0 [370.0-658.0] 384.0 [170.0-596.5] 214.0 [126.5-496.5] 183.0 [117.0-433.5] 162.0 [107.5-379.0]
Creatinine (μmol/L) [IQR]
 SUG < 4 mg/kg (101 pts) 757.0 [592.0-944.0] 605.0 [502.0-744.0] 484.0 [367.0-642.0] 360.0 [170.0-611.0] 228.0 [134.0-500.0] 185.0 [126.0-437.0] 168.0 [121.0-399.0]
 SUG ≥ 4 mg/kg (74 pts) 763.5 [573.0-953.0] 564.5 [461.5-798.5] 511.5 [378.5-680.5] 400.5 [173.5-569.0] 208.0 [119.7-494.0] 169.0 [104.7-422.0] 155.0 [100.0-362.0]
Urea (mmol/L) [IQR]
 NEO 18.7 [13.85-24.95] 17.1 [13.1-22.0] 17.5 [13.5-21.8] 17.9 [12.4-24.9] 16.4 [10.4-25.4] 15.8 [9.9-27.6] 14.7 [9.6-25.3]
 SUG 17.6 [13.62-23.6] 14.9 [10.8-21.6] * 15.3 [11.3-19.8] * 15.9 [8.8-20.5] * 14.9 [7.5-20.7] * 14.2 [7.7-23.0] 12.9 [7.7-24.7]
Urea (mmol/L) [IQR]
 SUG < 4 mg/kg (101 pts) 17.44 [13.93-24.09] 15.48 [11.96-22.82] 15.9 [11.5-19.7] 16.4 [10.0-20.6] 14.7 [8-20.8] 14.4 [8.45-22.8] 14.37 [8.2-23.9]
 SUG ≥ 4 mg/kg (74 pts) 17.6 [12.5-23.42] 14.3 [10.3-20.64] 14.45 [11.0-19.8] 14.7 [7.45-20.47] 15.1 [6.69-20.7] 13.35 [7.12-23.32] 12.5 [7.2-25.5]
eGFR [IQR]
 NEO 6.0 [5.0-8.0] 8.0 [6.0-10.0] 9.0 [7.0-14.0] 13.0 [7.5-29.0] 21.0 [9.0-43.5] 31.0 [11.0-51.0] 35.0 [12.2-53.7]
 SUG 6.0 [5.0-8.0] 8.0 [6.0-11.0] * 10.0 [7.0-14.5] 14.0 [8.0-36.0] 23.0 [10.0-52.5] 32.0 [12.0-59.5] 36.0 [14.0-61.0]
eGFR [IQR]
 SUG < 4 mg/kg (101 pts) 6.0 [5.0-8.0] 8.0 [6.0-11.0] 10.0 [7.0-15.0] 15.0 [8.0-38.0] 23.0 [10.0-52.0] 32.0 [13.0-55.0] 36.0 [14.0-56.0]
 SUG ≥ 4 mg/kg (74 pts) 6.0 [5.0-8.0] 8.0 [6.0-10.0] 9.0 [6.0-12.75] 14.0 [8.0-33.75] 26.0 [10.0-54.0] 33.0 [12.0-63.75] 37.0 [15.0-64.0]
  1. NMB neuromuscular block, NEO group of patients receiving neostigmine for reversal of cisatracurium-induced NMB, SUG group of patients receiving sugammadex for reversal of rocuronium-induced NMB, SUG <4 mg/kg and SUG ≥4 mg/kg sugammadex dose per kg of body weight for reversal of moderate or deep NMB, respectively, baseline value before kidney transplantation, DO-D5 values obtained the day of kidney transplantation (D0) and in each of the following five postoperative days (D1-D5), eGRF estimated glomerular filtration rate, creatinine and urea serum creatinine and serum urea, eGRF estimated glomerular filtration rate. Data are expressed as median [interquartile range, IQR]. (*) = significant p value (< 0.05) at intergroups analysis