Fig. 1From: Gestational hemostasis: a natural model for hemostasis resuscitation of major periprocedural blood lossComparison of global gestational hemostasis (A) with the pyramid of interventions (B) and the relevant steps of the algorithms reflecting the early, goal-directed, individualized, point-of-care-controlled hemostasis resuscitation (C). The analogy between the gestational adaptation as a natural prothrombotic mechanism and the therapeutic algorithms is remarkable (red arrows). (Abbreviations: ASA: aspirin, Ch: chapter, DOAC: direct acting oral anticoagulants, EXTEM: extrinsically triggered rotational thromboelastometry, FF-TEG functional fibrinogen TEG, FIBTEM: cytochalasin D added EXTEM test, FFP: fresh frozen plasma, FVII: coagulation factor VII, FXIII: coagulation factor XIII, Hb: hemoglobin, INTEM: intrinsically triggered rotational thromboelastometry, k-TEG: kaolin TEG, PAI-1: plasminogen activator inhibitor 1, PAI-2: plasminogen activator inhibitor 2, PT: prothrombin time, PTT: partial prothrombin time, rFVIIa: recombinant activated factor VII, (r)FXIII(a): recombinant activated factor XIII, r-TEG: rapid TEG, TAFI: thrombin-activatable-fibrinolysis-inhibitor, TEG: thromboelastography, t-PA: tissue plasminogen activator, TXA: tranexamic acid, vWF: von-Willebrandt factor, 4F PCC: four-factor prothrombin complex concentrate)Back to article page