Deep neuromuscular block reduces the incidence of intra-operative complications during laparoscopic donor nephrectomy: a pooled analysis of randomized controlled trials

Table 4 Postoperative complications (Clavien-Dindo grade ≥ 2) and hospital admission

	A	B	C	D
Intra-abdominal pressure^g	Standard	Standard	Low	Low
Neuromuscular blockade^h	Moderate	Deep	Moderate	Deep
	(n = 298)	(n = 78)	(n = 29)	(n = 48)
Postoperative complications (Clavien-Dindo grade ≥ 2)
Total number	17 (5.7%)^a,d,e	9 (11.5%)^a,c,f	2 (6.9%)^b,c,e	3 (6.3%)^b,d,f
Grade 2	17 (5.7%)	9 (11.5%)	2 (6.9%)	2 (4.2%)
Grade 3	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (2.1%)
Type of complication
Infection	8 (47.1%)	7 (77.8%)	0 (0.0%)	0 (0.0%)
Bleeding	3 (17.6%)	0 (0.0%)	0 (0.0%)	0 (0.0%)
Ileus/gastroparesis	2 (11.8%)	1 (11.1%)	0 (0.0%)	1 (33.3%)
Otherⁱ	4 (23.5%)	1 (11.1%)	2 (100%)	2 (66.7%)
Length of hospital admission (days)	4.0 (±0.9)	3.7 (±1.0)	4.7 (±1.3)	3.9 (±1.3)

Chi square testing: ^aA vs B, p = 0.097; ^bC vs D, p = 0.917; ^cB vs C, p = 0.522; ^dA vs D, p = 0.887; ^eA vs C, p = 0.806; ^fB vs D, p = 0.369
^gStandard pressure 12–14 mmHg; low pressure 6–7 mmHg
^hModerate blockade: single dose rocuronium or TOF count 1–2; deep blockade: PTC 1–2 or PTC 1–5
ⁱHypertension (3×), atrial fibrillation/supraventricular tachycardia (2×), pneumothorax (1×), meatus stenosis (1×), respiratory insufficiency, no diagnosis reported (1×), subcutaneous emphysema (1×)

ISSN: 2047-0525