5-HT3 receptor antagonists decrease the prevalence of postoperative delirium in older patients undergoing orthopedic lower limb surgery

Table 2 Multivariable logistic regression analysis for postoperative delirium

Variable	Multivariate logistic model
Variable	OR	95% CI	P value
Age	1.11	1.04–1.79	0.002
BMI	0.89	0.79–0.98	0.016
Charlson comorbidity index	1.95	1.30–2.93	0.001
Urgency of surgery
Elective	1
Emergency	7.84	1.55–39.64	0.013
Type of surgery
Non-hip	1
Hip	6.91	3.25–14.66	< 0.001
Sedative
Propofol	1
Dexmedetomidine	0.20	0.08–0.58	0.002
5-HT₃ receptor antagonists
No	1
Yes	0.37	0.15–0.94	0.036
5-HT₃ receptor antagonists			(0.047)
None	1
Ramosetron	0.48	0.17–1.33	0.157
Palonosetron	0.28	0.10–0.77	0.014

For final multivariable model, backward variable-selection method was performed (removed variables: gender, ASA classification, hypertension, diabetes mellitus, history of stroke, chronic kidney disease, midazolam premedication, operation time, RBC transfused, phenylephrine, ephedrine, laboratory findings, and ICU admittance)
CI confidence interval, BMI body mass index, 5-HT 5-hydroxytryptamine, ASA American Society of Anesthesiologists, RBC red blood cell, ICU intensive care unit

ISSN: 2047-0525