Table 1 The course of plasma syndecan level, cardiac index, mean arterial pressure, temperature, haemoglobin level, vasopressor dose, lactate level, fluid balance and SOFA score. The values are presented as median with interquartile range. Friedman test was used to analyse changes over time

Syndecan level (ng/ml), n

-

47.0 (43), 25

79.5 (90), 25

-

67.4 (86), 25

-

-

61.1 (44), 25

-

-

0.0008

Cardiac index (l/min/m²), n

-

2.1 (0.8), 25

3.3 (0.9), 25

3.3 (1.0), 15

-

-

-

-

-

-

0.03

MAP (mmHg), n

109 (17), 25

78 (14), 25

80 (24), 25

77 (24.5), 25

76 (23), 25

75 (19), 25

83 (25.5), 25

82 (23), 25

84 (20.5), 25

83 (19), 25

< .0001

Temperature (°C), n

36,0 (1), 25

36,0 (0.7), 25

36,6 (0.6), 25

36,9 (0.7), 25

37,0 (0.6), 25

37,0 (0.4), 25

37,2 (0.3), 25

36,9 (0.3), 25

36,8 (0.5), 25

36,9 (0.6), 25

< .0001

Haemoglobin (g/dl), n

12.8 (1.8), 25

12.0 (1.7) , 24

12.2 (2.9), 24

11.4 (2.9), 18

9.8 (2.6), 24

9.9 (2.0), 10

9.5 (1.9), 10

8.6 (1.8), 17

9.8 (1.5), 8

9.3 (2.0), 9

< .0001

Norepinephrine dose (μg/kg/min), n

0.0 (0), 25

0.0 (0), 25

0.04 (0.07), 25

0.0 (0), 25

0.00 (0), 25

0.0 (0), 25

0.0 (0), 25

0.0 (0), 25

0.0 (0), 25

0.0 (0), 25

< .0001

Lactate level (mg/dl), n

-

8.0 (1.7), 20

10.2 (4.7), 24

11.5 (5.4), 18

14.7 (7.6), 13

15.4 (12.2), 9

16.4 (9.3), 9

11.3 (5.7), 9

10.9 (4.0), 8

10.0 (3.7), 9

0.0001

Fluid balance (ml), n

-

0, 25

1700 (750), 25

2560 (1233), 25

2399 (2140), 25

2452 (1787), 25

2640 (1576), 25

2536 (2172), 22

2478 (2602), 22

2551 (3898), 22

SOFA score, n

0 (1), 25

-

-

3 (3), 25

2 (2), 25

-

-

1 (2), 22

-

-

0.0012