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Table 2 Interrupted time series analysis examining pain medication utilization pre- and post-intervention

From: Enhanced recovery after surgery protocol and postoperative opioid prescribing for cesarean delivery: an interrupted time series analysis

 

Coefficient

95% CI low

95% CI high

P value

Proportion prescribed tylenol 24 h prior to discharge

 Pre-ERAS trend (Jan 2015–Sep 2016)

0.01

0.01

0.01

<0.01

 Level shift after ERAS implementation

0.77

0.75

0.78

<0.01

 Trend shift after ERAS implementation

− 0.01

− 0.01

− 0.01

<0.01

 Post-ERAS trend (Feb 2017–Dec 2019)

0.00

0.00

0.00

<0.01

Proportion prescribed NSAIDs 24 h prior to discharge

 Pre-ERAS trend (Jan 2015–Sep 2016)

0.01

0.00

0.03

0.12

 Level shift after ERAS implementation

− 0.07

− 0.20

0.05

0.25

 Trend shift after ERAS implementation

− 0.01

− 0.02

0.01

0.38

 Post-ERAS trend (Feb 2017–Dec 2019)

0.00

0.00

0.01

<0.01

Mean OME administered in 24 h prior to discharge

 Pre-ERAS trend (Jan 2015–Sep 2016)

− 0.45

− 0.60

− 0.29

<0.01

 Level shift after ERAS implementation

− 2.27

− 4.64

0.10

0.06

 Trend shift after ERAS implementation

0.37

0.22

0.53

<0.01

 Post-ERAS trend (Feb 2017–Dec 2019)

− 0.07

− 0.13

− 0.02

0.01

Total OME prescribed at discharge

 Pre-ERAS trend (Jan 2015–Sep 2016)

− 2.26

− 3.54

− 0.98

<0.01

 Level shift after ERAS implementation

− 51.50

− 95.97

− 7.04

0.02

 Trend shift after ERAS implementation

− 1.52

− 3.34

0.29

0.10

 Post-ERAS trend (Feb 2017–Dec 2019)

− 3.78

− 5.59

− 1.97

<0.01

Daily OME prescribed at discharge

 Pre-ERAS trend (Jan 2015–Sep 2016)

− 0.48

− 0.75

− 0.22

<0.01

 Level shift after ERAS implementation

34.83

29.13

40.53

<0.01

 Trend shift after ERAS implementation

− 0.89

− 1.22

− 0.57

<0.01

 Post-ERAS trend (Feb 2017–Dec 2019)

− 1.38

− 1.62

− 1.13

<0.01

Proportion prescribed opioid refill within 90 days after discharge

 Pre-ERAS trend (Jan 2015–Sep 2016)

− 0.03%

− 0.25%

0.18%

0.77

 Level shift after ERAS implementation

− 4.96%

− 9.68%

− 0.24%

0.04

 Trend shift after ERAS implementation

0.01%

− 0.23%

0.26%

0.91

 Post-ERAS trend (Feb 2017–Dec 2019)

− 0.02%

− 0.19%

0.15%

0.85

  1. OME oral morphine equivalents, ERAS enhanced recovery after surgery, NSAIDS non-steroidal anti-inflammatory drugs, CI confidence interval