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Table 3 dNCR in relation to biochemical characteristics, MTHFR rs1801133 and rs1801131

From: Association between preoperative serum homocysteine and delayed neurocognitive recovery after non-cardiac surgery in elderly patients: a prospective observational study

 

dNCR group

(n = 36)

non-dNCR group

(n = 139)

P value

Biochemical measures

 Homocysteine (μmol/L)

12.8 (10.9, 14.4)

10.6 (8.6, 14.7)

0.02*

 Folate (ng/mL)

5.3 (4.2, 7.3)

6.9 (5.3, 9.5)

0.01†

 Vitamin B12 (pg/mL)

284 (230, 393)

360 (252, 509)

0.05

MTHFR SNPs

 rs1801133

Allele

C

25 (34.7%)

104 (37.4%)

0.67

T

47 (65.3%)

174 (62.6%)

 

Genotype

CC

6 (16.7%)

25 (18.0%)

 

CT

13 (36.1%)

54 (38.8%)

 

TT

17 (47.2%)

60 (43.2%)

 
 

0.91

 rs1801131

Allele

A

62 (86.1%)

241 (86.7%)

0.90

C

10 (13.9%)

37 (13.3%)

 

Genotype

AA

27 (75.0%)

105 (75.5%)

 

AC

8 (22.2%)

31 (22.3%)

 

CC

1 (2.8%)

3 (2.2%)

 
 

1.00

  1. Results of biochemical measures are shown as median [interquartile range (IQR)] and P value for Mann-Whitney tests. Categorical variables are presented as frequency (%) and P value for chi-square test
  2. Abbreviations: CI confidence interval, MTHFR methylenetetrahydrofolate reductase
  3. *P < 0.05
  4. †P < 0.01
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Perioperative Medicine

ISSN: 2047-0525