Skip to main content

Table 3 Population kinetic parameters in the final model

From: Distribution of crystalloid fluid infused during onset of anesthesia-induced hypotension: a retrospective population kinetic analysis

 

Covariate

Best estimate

95% CI

RSE

Bootstrap

95% CI

Kinetic parameter

 Vc (L)

 

2.15

1.88–2.42

6.4

1.88–2.45

 k12 (10−3 min−1)

 

22.1

15.3–28.8

15.6

16.3–29.1

 k10 (10−3 min−1)

 

5.1

3.9–6.4

12.1

4.0–6.5

Covariate effects

 Vc

Body weight

0.86

0.51–1.21

19.8

0.51–1.16

 k12

MAP

2.34

1.87–2.82

10.4

1.65–3.36

 k10

MAP

3.73

1.99–5.47

23.7

2.31–5.74

  1. Vc central volume of distribution; conversion factor between plasma dilution and plasma volume expansion, k12 rate constant for translocation of fluid from Vc to the extravascular fluid space, k10 rate constant governing urinary excretion, CI confidence interval, RSE standard error/best estimate
Back to article page

Perioperative Medicine

ISSN: 2047-0525