Optimization routine | Model | Target parameter | LL | −2 (LL) | AIC |
---|---|---|---|---|---|
Naive pooled | 5 parameters (Vc, k12, k21, k10, and kb) | 340 | −681 | −631 | |
Naive pooled | Removal of first fixed parameter | kb | 341 | −681 | −669 |
FOCE ELS | Removal of first fixed parameter | kb | 1280 | −2560 | −2540 |
FOCE ELS | Removal of second fixed parameter | k21 | 1541 | −3081 | −3065 |
FOCE ELS | Add covariate: body weight | Vc | 1558 | −3117 | −3099 |
Add covariate: crude MAP | k12 | 1605 | −3210 | −3190 | |
FOCE ELS | Add covariate: crude MAP | k10 | 1632 | −3264 | −3242 |
FOCE ELS | Full block model | All the above | 1652 | −3304 | −3276 |
FOCE ELS | Bootstrap analysis | All the above | 1652 | −3304 | −3246 |