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Fig. 2 | Perioperative Medicine

Fig. 2

From: Distribution of crystalloid fluid infused during onset of anesthesia-induced hypotension: a retrospective population kinetic analysis

Fig. 2

Distribution of observations of plasma dilution (A) and mean arterial pressures (B) and the relationship between these variables (C) throughout the study in all 76 patients, illustrating the limits for simulation by using the kinetic parameters. (D) Decrease in rate parameters for lower mean arterial pressures. (E) Predictive check showing the original data (blue points) with their confidence limits (red). The confidence limits based on 1000 simulations using the model parameters in the final model are superimposed (green lines). Hatched pattern is due to different sampling times. A small difference between observed and predicted confidence limits is a sign of good model performance. The difference between observed and predicted dilution averaged 0.03 (0.02) at the 5% level, −0.01 (0.05) at the 50% level, and −0.06 (0.06) dilution units at the 95% level

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