Influence of sugammadex versus neostigmine for neuromuscular block reversal on the incidence of postoperative pulmonary complications: a meta-analysis of randomized controlled trials

Wang, Jia-Feng; Zhao, Zhen-Zhen; Jiang, Zheng-Yu; Liu, Hui-Xing; Deng, Xiao-Ming

doi:10.1186/s13741-021-00203-6

Perioperative Medicine

Table 1 Characteristics of the included RCTs

From: Influence of sugammadex versus neostigmine for neuromuscular block reversal on the incidence of postoperative pulmonary complications: a meta-analysis of randomized controlled trials

Study	Country	Design	Patients and surgeries	Sample size	Mean age	Male	Neuromuscular blocking agent	Sugammadex dose	Neostigmine dose	Secondary PPCs reported^a
					years	%
Schaller et al., 2010	Germany	R, DB	ASA I–III, various surgery type	94	42	54	Rocuronium	0.0625, 0.125, 0.25, 0.5, or 1.0 mg/kg	5, 8, 15, 25, or 40 μg/kg	A
Geldner et al., 2012	Germany	R, DB	ASA I–III, laparoscopic surgery	133	51	31	Rocuronium	4 mg/kg	50 μg/kg	A
Carron et al., 2013	Italy	R	ASA I–III, obese patients for laparoscopic removal of adjustable gastric banding	40	43	30	Rocuronium	4 mg/kg	70 μg/kg	A
Koyuncu 2014	Turkey	R, DB	ASA I–II, extremity surgery	100	27	54	Rocuronium	2 mg/kg	70 μg/kg	A
Brueckmann et al., 2015	USA	R, DB	ASA I–III, elective laparoscopic or open abdominal surgery	151	57	60	Rocuronium	2 or 4 mg/kg	17.1–84.8 μg/kg	A, B
Unal et al., 2015	Turkey	R	ASA I–II, surgery for OSA	74	46	NR	Rocuronium	2 mg/kg	40 μg/kg	A
Hakimoglu et al., 2016	Turkey	R	ASA I–II, arthroscopic surgery	60	34	65	Rocuronium	4 mg/kg	50 μg/kg	A
Loh 2017	Malaysia	R, DB	ASA I–III, various surgery type	120	44	48	Rocuronium	2 mg/kg	20 μg/kg	A
Yagan et al., 2017	Turkey	R, SB	ASA I–II, various surgery type	98	40	65	Rocuronium	2 mg/kg	50 μg/kg	A
Alday et al., 2019	Spain	R, SB	ASA I–IV, major abdominal surgery	126	68	51	Rocuronium	4 mg/kg	40 μg/kg	A, B, C
Claroni et al., 2019	Italy	R, DB	ASA I–III, robot-assisted radical cystectomy for bladder cancer	109	62	83	Rocuronium	2 mg/kg	40 μg/kg	A
Togioka et al., 2020	USA	R, OL	ASA I–IV, various surgery type	200	75	46	Rocuronium	2 mg/kg	70 μg/kg	A, B, C, D
Lee et al., 2020	South Korea	R, SB	ASA I–II, elective laparoscopic cholecystectomy	73	56	48	Rocuronium	4 mg/kg	40 μg/kg	A
Ba et al., 2020	China	R	ASA I–II, radical resection of lung cancer under thoracoscope	100	50	51	Rocuronium	2 mg/kg	2 mg	A

RCTrandomized controlled trial; R randomized; DB double-blind; SB single-blind; OL open-label; ASA American Society of Anesthesiology; OSA obstructive sleep apnea.
^aIndicators for secondary PPCs: A, respiratory failure; B, respiratory infection; C, atelectasis; and D, pneumothorax

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ISSN: 2047-0525

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