Table 1 Main characteristics of included studies
Trail | Single/multicenter | Country | Type of surgery | No. of patients | Comparators | Volume of HES 130/0.4 | GDFT | Outcomes | Jadad score |
|---|---|---|---|---|---|---|---|---|---|
Alavi, 2012 | Single | Iran | Cardiac | 92 | RL, 4% gelatin | 1320 ± 250 mL | No | Mortality | 3 |
Duncan, 2020 | Single | USA | Cardiac | 141 | 5% HA | 500 (400–750) mL | No | AKI, RRT | 5 |
Feldheiser, 2013 | Single | Germany | Gynecological | 50 | Balanced crystalloid | Not available | Yes | Mortality, AKI | 4 |
Futier, 2020 | Multi | France | Abdominal | 775 | 0.9% saline | 1000 (750–1500) mL | Yes | Mortality, AKI, RRT | 5 |
Ghodraty, 2017 | Single | USA | Abdominal | 91 | RL | 10.4 ± 4.1 mL/kg | No | AKI | 5 |
Godet, 2008 | Multi | France | Vascular | 65 | 3% gelatin | 1431 ± 731 mL (19.7 ± 9.9 mL/kg) | No | Mortality, AKI, RRT | 4 |
Gondos, 2010 | Multi | Hungary | mixed | 200 | RL, 4% gelatin, 5% HA | 10 ml/kg | No | Mortality | 3 |
Hamaji, 2013 | Single | Brazil | Orthopedic | 48 | RL | 15 ml/kg | No | Mortality, AKI | 4 |
Hung, 2014 | Single | China | abdominal | 80 | RL | 999.1 ± 369.3 mL | No | Mortality, AKI | 4 |
Joosten, 2018 | Multi | Belgium | Abdominal | 160 | Balanced crystolloid | 900 (400–1300) mL | Yes | Mortality, AKI ,RRT | 5 |
Kabon, 2019 | Multi | Austria, USA | Abdominal | 1057 | RL | 1000 (500–1500) mL | Yes | Mortality, AKI, RRT | 5 |
Kammerer, 2018 | Single | Germany | Urological | 100 | 5% HA | 2955 ± 1043 mL | No | AKI | 3 |
Lee, 2011 | Single | Republic of Korea | Cardiac | 106 | Crystalloid (plasma solution A) | 1458 ± 465 mL | No | AKI, RRT | 1 |
Lindroos, 2013 | Single | Finland | Neurological | 30 | RL | 464 ± 284 mL | Yes | Mortality, AKI | 3 |
Mahmood, 2007 | Single | UK | Vascular | 62 | HES 200/0.62, 4% gelatin | 3911 ± 1783 mL | No | Mortality, RRT | 3 |
Ooi, 2009 | Single | Malaysia | Cardiac | 90 | 4% gelatin | 1942.3 ± 1046.1 mL | No | Mortality | 2 |
Rasmussen, 2014 | Single | Denmark | Abdominal | 33 | RL | 2605 ± 512 mL | Yes | Mortality | 5 |
Skhirtladze, 2014 | Single | Austria | Cardiovascular | 236 | RL, 5% HA | 42 (35–48) mL/kg 2500 (2250 –2750) mL | No | RRT | 5 |
Szturz, 2014 | Single | Czech Republic | Urological | 115 | RL | 1500 (400–3500) mL | Yes | Mortality | 5 |
Tyagi, 2019 | Single | India | Orthopedic | 38 | RL | 689 ± 394 mL | Yes | AKI | 5 |
Van der Linden, 2005 | Single | Belgium | Cardiac | 132 | 3% gelatin | 21.3 ± 8.3 mL/kg | Yes | Mortality | 3 |
Verheij, 2006 | Single | Netherlands | Cardiovascular | 67 | 0.9% saline, 4% gelatin, 5% HA | 1600 (750–1800) mL | No | Mortality | 3 |
Yang, 2011 | Single | China | Abdominal | 90 | RL, 20% HA | 3484.6 ± 1072.5 mL | No | Mortality | 2 |
Yates, 2014 | Single | UK | Abdominal | 202 | Balanced crystalloid | 1875 (1500–3000) mL | Yes | Mortality, AKI | 5 |
Zhang, 2012 | Single | China | Abdominal | 60 | RL | 865.0 ± 297.4 mL | Yes | Mortality, AKI | 5 |