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Table 1 List of causes of hyperchloremia

From: Clinical physiology aspects of chloremia in fluid therapy: a systematic review

Mechanism

Site of action

Example

Chloride intake

 

Fluid therapy with high-chloride solutions

Total parenteral nutrition

Loss of water

Kidney

Diabetes insipidus

Diuretics

A polyuric phase of renal failure

 

Other than the kidney

Fever

Hypermetabolism

Diarrhea

Burns

Exercise and severe dehydration

An absolute or relative increase in chloride tubular reabsorption rates

 

Renal tubular acidosis

Renal failure

Acetazolamide

Reconstructive surgery of lower urinary tract for urine derivation

Post-hypocapnia states

  1. Adapted from Bandak G, Kashani KB. Chloride in intensive care units: a key electrolyte. F1000Res. 2017; 6:1930