Table 4 Risk factors of major postoperative bleeding
p value univariate | p value multivariate | Odds ratio (95% CI) | |
|---|---|---|---|
Procedure-specific risk of bleeding | 0.003 | 0.008 | 1.8 (1.2–2.9) |
HAS-BLED score | 0.31 | ||
Malignant tumor | 0.52 | ||
Age > 65 years | 0.084 | ||
Arterial hypertension | 0.041 | ||
Congestive heart failure | 0.039 | ||
Renal insufficiency (GFR < 60) | < 0.0001 | < 0.0001 | 5.8 (2.3–14.6) |
Hemoglobin level | 0.82 | ||
International normalized ratio (INR) | 0.072 | ||
Platelet count | 0.77 | ||
Perioperative bridging | < 0.0001 | ||
Full-therapeutic dose of LMWH | < 0.0001 | < 0.0001 | 18.7 (3.6–95) |
Preoperative interruption of LMWH ≤ 24 h | 0.007 | ||
Postoperative interruption of LMWH ≤ 24 h | 0.006 | 0.068 | 1.5 (0.9–2.2) |