Markedly increased risk of postoperative bleeding complications during perioperative bridging anticoagulation in general and visceral surgery

Table 3 Postoperative complications and patient outcome

		Bridging group	Control group	p value¹
Thromboembolic events [n, %]		2 (0.8%)	5 (1.9%)	0.45
Postoperative bleeding²	Major [n, %]	22 (8.4%)	2 (0.8%)	< 0.0001
Postoperative bleeding²	Minor [n, %]	36 (13.7%)	14 (5.3%)	0.001
Red blood cell transfusion [n, %]		23 (8.7%)	2 (0.8%)	< 0.0001
Reoperation [n, %]		40 (15.2%)	14 (5.4%)	< 0.0001
Classification of complications³	Grade IIIa–V [n, %]	61 (23.2%)	33 (12.5%)	0.001
Classification of complications³	Grade IVa–V [n, %]	18 (6.8%)	8 (3%)	0.044
In-hospital mortality [n, %]		4 (1.5%)	5 (1.9%)	1.0
Intermediate care/intensive care [n, %]		118 (44.9%)	74 (28.1%)	< 0.0001
Length of stay [days]		12 ± 11	9 ± 9	0.009

¹p values of continuous outcomes were calculated by a two-sided two-sample t test assuming equal variances; p values of categorical outcomes were calculated by a two-sided χ² test or, in case of categories with less than 5 subjects, by Fisher’s exact test
²According to the International Society on Thrombosis and Haemostasis (Schulman et al. 2010)
³According to Clavien-Dindo (Dindo et al. 2004)

ISSN: 2047-0525