Goal-directed haemodynamic therapy (GDHT) in surgical patients: systematic review and meta-analysis of the impact of GDHT on post-operative pulmonary complications

Dushianthan, Ahilanandan; Knight, Martin; Russell, Peter; Grocott, Michael PW

doi:10.1186/s13741-020-00161-5

Perioperative Medicine

Table 2 Summary characteristics of included studies.

From: Goal-directed haemodynamic therapy (GDHT) in surgical patients: systematic review and meta-analysis of the impact of GDHT on post-operative pulmonary complications

Author/year	No. of patients	Single/multicenter	Type of surgery	Timing	Fluids/fluids & inotropes (I) or vasopressors (V)	Goals
Ackland, 2015	204	Multi	Elective	Post-operative	Fluids & I/V	SV, CO, DO2I
Bahlmann, 2019	59	Multi	Elective	Intra/post-operative	Fluids & I/V	SV, CI, MAP
Bartha, 2013	149	Single	Emergency	Pre/intra-operative	Fluids & I/V	SV, DO₂I
Bender 1997	104	Single	Elective	Pre/intra/post-operative	Fluids & I/V	SVR, CI, PAOP
Benes, 2010	120	Single	Elective	Intra-operative	Fluids & I/V	SVV, CI
Bisgaard, 2013a, b	70	Single	Elective	Intra/post-operative	Fluids & I/V	SVI, DO₂I
Bisgaard, 2013a, b	40	Single	Elective	Intra/post-operative	Fluids & I/V	SVI, DO₂I
Boyd, 1993	107	Single	Mixed	Pre/intra/post-operative	Fluids & I/V	DO₂I
Brandstrup, 2012	151	Multi	Elective	Intra-operative	Fluids	SV
Calvo-Vecino, 2018	450	Multi	Elective	Intra-operative	Fluids & I/V	SV, CI
Cecconi, 2011	40	Single	Elective	Intra/post-operative	Fluids & I/V	SV, DO₂I
Colantonio, 2015	86	Single	Elective	Intra-operative	Fluids & I/V	SVI, CI
Correa-Gallego, 2015	135	Single	Elective	Intra-operative	Fluids	SVV
Davies, 2019	241	Multi	Emergency	Intra-operative	Fluids	SV
Donati, 2007	135	Multi	Elective	Intra/post-operative	Fluids & I/V	O₂ER
El-Sharkawy, 2013	59	Single	Elective	Intra/post-operative	Fluids	SV, FTc
Funk, 2015	40	Single	Elective	Intra-operative	Fluids & I/V	SVV, CI
Gan, 2002	100	Single	Elective	Intra-operative	Fluids	SV, FTc
Gerent, 2018	128	Single	Elective	Post-operative	Fluids & I/V	SVI, CI
Goepfert, 2013	100	Single	Elective	Intra/post-operative	Fluids & I/V	GEDI, SVV, CI
Gómez-Izquierdo, 2017	135	Single	Elective	Intra-operative	Fluids	SV
Han, 2016	40	Single	Elective	Intra-operative	Fluids	SVV
Jammer, 2010	241	Multi	Elective	Intra/post-operative	Fluids	ScVO₂
Jammer, 2015	30	Multi	Elective	Intra-operative	Fluids & I/V	SVV
Joosten, 2019	39	Single	Elective	Intra-operative	Fluids	CI, SVV
Kaufmann, 2017	100	Single	Elective	Intra-operative	Fluids & I/V	SV, CI
Kaufmann, 2018	90	Single	Mixed	Intra-operative	Fluids & I/V	SV, CI
Kim, 2018	62	Single	Elective	Intra-operative	Fluids & I/V	SVV, CI
Kumar, 2016	60	Single	Elective	Intra-operative	Fluids & I/V	SVV, SVR
Lobo, 2000	37	Single	Elective	Intra/post-operative	Fluids & I/V	DO₂, PAOP
Luo, 2017	150	Single	Elective	Intra-operative	Fluids & I/V	SVV, CI
Mayer, 2010	60	Single	Elective	Intra-operative	Fluids & I/V	CI, SVI
McKendry, 2004	179	Single	Mixed	Post-operative	Fluids & I/V	SI
McKenny, 2013	102	Single	Elective	Intra-operative	Fluids	SV
Mikor, 2015	84	Single	Elective	Intra-operative	Fluids & I/V	ScVO₂
Moppett, 2015	130	Single	Emergency	Intra-operative	Fluids	SV
Mythen, 1995	60	Single	Elective	Intra-operative	Fluids	SV, CVP
Osawa, 2016	126	Single	Elective	Intra/post-operative	Fluids & I/V	SVI, CI
Pearse, 2005	122	Single	Mixed	Post-operative	Fluids & I/V	SV, DO₂I, CI
Pearse, 2014	734	Multi	Mixed	Intra/post-operative	Fluids & I/V	SV
Peng, 2014	80	Single	Elective	Intra-operative	Fluids	SVV
Pestaña, 2014	170	Multi	Elective	Intra/post-operative	Fluids & I/V	SV, CI, MAP
Phan, 2014	100	Single	Elective	Intra-operative	Fluids	SVI, FTc
Reisinger, 2017	58	Single	Elective	Intra/post-operative	Fluids	SVI
Salzwedel, 2013	180	Multi	Elective	Intra-operative	Fluids & I/V	PPV, CI
Sandham, 2003	1994	Multi	Mixed	Pre-operative	Fluids & I/V	DO₂I, CI
Scheeren, 2013	64	Multi	Elective	Intra-operative	Fluids	SVV, SV
Schmid, 2016	193	Single	Elective	Intra/post-operative	Fluids & I/V	GEDI, CI
Senagore, 2009	64	Single	Elective	Intra-operative	Fluids	SV
Shoemaker, 1998	88	Single	Mixed	Pre-operative	Fluids & I/V	CI, DO₂I, VO₂I
Sinclair, 1997	40	Single	Emergency	Intra-operative	Fluids	SV, FTc
Stens, 2017	244	Multi	Elective	Intra-operative	Fluids & I/V	CI, PPV
Ueno, 1998	34	Single	Elective	Post-operative	Fluids & I/V	CI, DO₂I, VO2I
Valentine, 1998	120	Single	Elective	Pre-operative	Fluids & I/V	PCWP, CI, SVR
Van der Linden, 2010	57	Single	Elective	Intra-operative	Fluids & I/V	CI
Venn, 2002	90	Single	Emergency	Intra-operative	Fluids	SV, FTc
Wakeling, 2005	134	Single	Elective	Intra-operative	Fluids	SV
Weinberg, 2017	52	Multi	Elective	Intra-operative	Fluids & I/V	SVV, CI
Weinberg, 2019	50	Multi	Elective	Intra-operative	Fluids & I/V	SVV, CI
Wilson, 1999	138	Single	Elective	Pre/intra/post-operative	Fluids & I/V	DO₂I
Wu, 2017	66	Single	Elective	Intra-operative	Fluids & I/V	SVV, CI
Xu, 2017	172	Single	Elective	Intra-operative	Fluids & I/V	SVV, CI
Yin, 2018	50	Single	Elective	Intra-operative	Fluids & I/V	SVV, CI
Zakhaleva 2013	91	Single	Elective	Intra-operative	Fluids	SV, FTc
Zeng, 2014	60	Single	Elective	Intra-operative	Fluids	SVV
Zhang, 2013	60	Single	Elective	Intra-operative	Fluids & I/V	SVV, CI

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