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Table 2 Clinicopathological and haematological factors associated with protocol-defined iron status prior to intravenous iron infusion for elective colorectal surgery for cancer (n = 47)

From: The impact of preoperative systemic inflammation on the efficacy of intravenous iron infusion to correct anaemia prior to surgery for colorectal cancer

Characteristic

Pre-infusion iron status

p

IDA

(CRP ≤ 5 + Fer < 30)

n (%)

FID

(CRP > 5 + Fer < 30)

n (%)

AOI

(CRP > 5 + Fer ≥ 30)

n (%)

Replete/other

(CRP ≤ 5 + Fer ≥ 30)

n (%)

Total

18 (38)

17 (38)

6 (12)

6 (12)

Patient characteristics

 Sex

  Male

13 (72)

10 (59)

1 (17)

3 (50)

0.120

  Female

5 (28)

7 (41)

5 (83)

3 (50)

 

 Age (years)

  < 65

1 (6)

5 (29)

1 (17)

1 (17)

0.261

  65–75

6 (33)

2 (12)

3 (50)

3 (50)

 

  > 75

11 (61)

10 (59)

2 (33)

2 (33)

 

 ASA

  1

0 (0)

2 (12)

0 (0)

0 (0)

0.070

  2

9 (50)

3 (17)

6 (100)

4 (67)

 

  3

8 (44)

11 (65)

0 (0)

2 (33)

 

  4

1 (6)

1 (6)

0 (0)

0 (0)

 

Pathologic characteristics

 TNM stage

  1

1 (6)

3 (18)

0 (0)

2 (33)

0.448

  2

11 (61)

5 (29)

3 (50)

3 (50)

 

  3

6 (33)

8 (47)

3 (50)

1 (17)

 

  4

0 (0)

1 (6)

0 (0)

0 (0)

 

 Tumour site

  Right colon

8 (44)

17 (100)

5 (83)

5 (83)

0.006

  Left colon

3 (17)

0 (0)

1 (17)

1 (17)

 

  Rectum

7 (39)

0 (0)

0 (0)

0 (0)

 

Infusion variables

 Total IV iron dose (mg)

  1000

7 (44)

6 (40)

0 (0)

3 (50)

0.254

  1500

4 (25)

7 (47)

4 (67)

3 (50)

 

  2000

5 (31)

2 (13)

2 (33)

0 (0)

 

 Days from infusion to surgery

  Median (range)

20 (3–83)

30 (7–62)

25 (19–44)

16 (2–48)

0.233

Haematological variables

 Pre-iron Hb (mg/L)

  Median (range)

100 (77–118)

102 (65–122)

110 (75–117)

110 (103–115)

0.101

 Δ Hb (mg/L)

     

  Median (range)

24 (− 6 to 48)

15 (− 15 to 63)

3 (− 11 to 34)

− 5 (− 10 to 8)

0.017

 POD1 Hb (mg/L)

  Median (range)

108 (87–133)

103 (87–138)

102 (74–113)

95 (85–99)

0.028

  1. AOI anaemia of inflammation, ASA American Society of Anesthesiology, CRP C-reactive protein (mg/L), Fer ferritin (μg/L), FID functional iron deficiency, Hb haemoglobin (g/L), IDA iron deficiency anaemia, IV intravenous, POD postoperative day