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Table 2 The conduct of the natriuretic-peptide (NP)-directed clinical trials

From: Natriuretic peptide-directed medical therapy: a systematic review

Clinical TrialLevel of care in interventional groupFrequency of visitsNP target
MurdochSpecialist HF clinicEvery 2 weeksSingle target BNP< 50 pg/ml
TroughtonSpecialist HF clinicEvery 3 monthsSingle target N-BNP < 200 pmol/L
Beck-da- SilvaNurse-led HF clinicEvery 3 monthsIndividualized according to symptoms in relation to BNP levels.
JourdainSpecialist care at the clinic1 month (for 3 months) then 3 monthsSingle target BNP < 100 pg/ml
OzkaraPhysician clinic visitsTreatment not adjusted throughout studyNo BNP target set
Lainchbury *Research clinic (with possible specialist input)Every 3 monthsSingle target NT-proBNP < 150 pmol/L
Maeder; PfistererOutpatients visits1, 3, 6, 12, 18 monthsNT-proBNP < 400 pg/ml in < 75 years and < 800 pg/ml in ≥ 75 years
EurlingsSpecialist care at the clinic2 weeks, 1 month, then 3 monthsIndividualized NT-proBNP < 10% of randomization level
Berger *HF specialist clinicEvery 2 weeks till NT-proBNP target met. Then as required.Single target NT-proBNP < 2200 pg/ml
PerssonPrimary care centres10 days, 1, 3, 6, 9 monthsIndividualized NT-proBNP < 50% from baseline level
AnguitaCardiology clinic1, 2, 3, 6, 24, 18 monthsSingle target BNP < 100 pg/ml
ShahHF clinic with specialist input1 week, 1, 2, 3, 4 months after dischargeIndividualized BNP < 2 times discharge level
JanuzziHF clinicEvery 3 monthsSingle target NT-proBNP ≤ 1000 pg/ml
KarlstromOutpatient visits2, 6, 10, 16, 2, 36, 48 weeks, then every 6 months< 75 years (BNP < 15 ng/L) and ≥75yrs (BNP < 300 ng/L)
SchouSpecialist heart failure clinicEvery 1–3 monthsIndividualised NT-proBNP < 30% of randomization level
CarubelliSingle center, initially in hospital management and then outpatient visitsFrequent visits if NT-proBNP still raised after discharge. Then telephonic follow up at 1, 3, and 6 monthsSingle target NT-proBNP≤ 3000 pg/ml
FelkerOutpatient visits2 and 6 weeks, then every 3 monthsSingle target NT-proBNP < 1000 pg/mL.
StienenIntervention carried out in the hospital1 week and at 1, 3, and 6 monthsIndividualized to reduce NT-proBNP by at least 30% by discharge
  1. NP natriuretic peptide, NT-proBNP N-terminal pro B-type natriuretic peptide, LVEF left ventricular ejection fraction, ARB angiotensin II receptor blocker, ACEIangiotensin-converting enzyme inhibitor, BNP B-type natriuretic peptide, NYHA New York Heart Association, HF heart failure
  2. *Lainchbury and Berger: three-arm trial but only NT-proBNP guided management group and usual care group compared