Table 1 Characteristics of included clinical trials
From: Natriuretic peptide-directed medical therapy: a systematic review
Clinical trial | Patients | Intervention arm (n) vs standard care arm (n)† | Follow-up (months) |
|---|---|---|---|
Murdoch et al. (1999) | Stable CHF, LVEF ≤ 35% | BNP arm n = 10 Standard care n = 10 | 2 |
Troughton et al. (2000) | Decompensated HF now stabilised, LVEF< 40% | BNP arm n = 33 Standard care n = 36 | 9.5 |
Beck-da-Silva et al. (2005) | > 18 years, stable CHF but not on β blockers, LVEF ≤ 40% | BNP arm n = 21 Standard care n = 20 | 3 |
Jourdain et al. (2007) | > 18 years, optimized on treatment, LVEF < 45% | BNP arm n = 110 Standard care n = 110 | 15 |
Ozkara et al. (2007) | Treated with ACEI/loop diuretic, LVEF ≤ 50% | NT-proBNP arm n = 79‡ Standard care n = 61 | 6 |
Pfisterer et al. (2009) | ≥ 60 years, LVEF≤v45%, 60–74 years=NT-proBNP ≥ 400 pg/ml; ≥ 75years = NT-proBNP 800 pg/ml | NT-proBNP arm n = 251 Standard care n = 248 | 18 |
Lainchbury et al. (2009)* | > 18 years, AHF now stabilised | NT-proBNP arm n = 121 Standard care n = 122 | 36 |
Anguita et al. (2010) | > 18 years, AHF | BNP arm n = 30 Standard care n = 30 | 18 |
Persson et al. (2010) | LVEF < 50%, males NT-proBNP > 800 ng/ml, females> 1000 ng/ml | NT-proBNP arm n = 125 Standard care n = 127 | 9 |
Eurlings et al. (2010) | AHF NT-proBNP > 1700, randomized at discharge if > 10% drop in NT-proBNP | NT-proBNP arm n = 174 Standard care n = 171 | 24 |
Berger et al. (2010)* | AHF now stabilised, LVEF < 40% | NT-proBNP + MC arm (only patients with NT-proBNP > 2200 pg/ml) n = 92 Standard care n = 90 | Maximum 18; minimum 12 |
Januzzi Jr et al. (2011) | > 21 years, LVEF < 40% | NT-proBNP arm n = 75 Standard care n = 76 | 10 |
Shah et al. (2011) | Decompensation HF now stabilized, LVEF ≤ 35% | BNP arm n = 68 Standard care n = 69 | 4 |
Karlstrom (2011) | > 18 years; BNP > 150 ng/L for those aged < 75 years, and BNP > 300 ng/L for those aged > 75 years | BNP arm n = 147 Standard care n = 132 | 33 |
Maeder et al. (2013) | ≥ 60 years, LVEF > 45%, 60–74 years = NT-proBNP ≥ 400 pg/ml; ≥ 75 years = NT-proBNP 800pg/ml | NT-proBNP arm n = 59 Standard care n = 64 | 18 |
Schou et al. (2013) | > 18years, Optimised on treatment and implantable ICD/CRT, LVEF < 45%, NT-proBNP > 1000 | NT-proBNP arm n = 199 Standard care n = 208 | Median 30 |
Carubelli et al. (2016) | Randomized after stabilization of AHF | NT-proBNP arm n = 137 Standard care n = 134 | Mean 18 |
Stienen et al. (2018) | Decompensated HF, NT-proBNP levels > 1700 ng/ml within 24 h of hospital admission. In hospital intervention | NT-proBNP arm n = 201 Standard care n = 203 | 6 |
Felker et al. (2017) | LVEF ≤ 40%, NT-proBNP > 2000 pg/mL/BNP > 400 pg/ml | NT-proBNP arm n = 446 Standard care n = 448 | 12 |