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Table 1 Trial characteristics of cardiac rehabilitation exercise trials

From: The role of cardiac rehabilitation using exercise to decrease natriuretic peptide levels in non-surgical patients: a systematic review

Author, yearPatient characteristicsType of NPBaseline NP in intervention group (pg/ml)
Kobayashi et al. 2003Stable NYHA II-III. EF < 40%BNP281 ± 92
Meyer et al. 2004Stable NYHAII-III. EF ≤ 40%NT-proBNP1092 ± 980
Jonsdottir et al. 2006Patients previously hospitalised in past 3 years for heart failureBNP173.2 ± 180.4
Maria Sarullo et al. 2006Stable CHF. EF < 40%NT-proBNP3376 pg/ml ± 3133
Brubaker et al. 2009CHF. EF ≤ 45%BNP176 ± 38
Malfatto et al. 2009Chronic heart failureBNP293 ± 115
Parrinello et al. 2010Stable NYHAII-III. EF ≤ 45%BNP205.2 ± 46.5
Gary et al. 2011Stable NYHA II-III, stable on medical therapy. EF 15 to 40%BNP184.4_151.6
Guazzi et al. 2012Stable NYHA class II or III, stable on medical therapy. EF ≤ 45%NT-proBNP1088.1 ± 447.1
Norman et al. 2012Volunteers, NYHAII-IV, ≥ 21 years, LVEF ≤ 40%, on optimal medical therapyBNP1088.1 ± 447.1
Sandri et al. 2012Stable CHF. EF < 40%NT-proBNP≤ 55 years, 1675 ± 354
≥ 65 years, 1301 ± 261
Eleuteri et al. 2013Stable NYHA II, stable on medical therapy. EF ≤ 40%NT-proBNP1570.7 ± 3125.8
Ahmad et al. 2014, HF-ACTION substudyCHF patients with reduced left ventricular ejection fraction (< 35%)NT-proBNP960.6 ± 1114
Aksoy et al. 2015NYHAII-III CHF on optimal medical therapy. EF 35 to 55%NT-proBNPContinuous aerobic exercise group 20.79 ± 12.8
Interval exercise group 24.00 ± 18.27
  1. NP natriuretic peptide, CHF chronic heart failure, EF left ventricular ejection fraction, BNP B-type natriuretic peptide, NT-proBNP N-terminal pro-B-type natriuretic peptide, NYHA New York Heart Association