Table 1 Summary of differences in renal function outcomes between non-buffered and buffered fluid groups
Outcomes | Absolute effects | No. of participants (studies) | p | |
|---|---|---|---|---|
Outcome with non-buffered fluid (mean) | Outcome with buffered fluid (mean; mean difference with 95% CI) | |||
Urine output—intraoperative | 799 ml | 872 ml (MD 6.1 ml higher; 95% CI − 128.4 to 140.6) | 459 (8 RCTs) | 0.93 |
Creatine change—postoperative | MD in creatinine was 7.0 μmol/L lower in the buffered fluids group; 95% CI − 27.4 to 13.5 | 113 (2 RCTs) | 0.50 | |
Creatine change—postoperative day 1 | MD in creatinine was 4.9 μmol/L lower in the buffered fluids group; 95% CI − 5.9 to 15.8 | 113 (2 RCTs) | 0.37 | |
Creatinine—postoperative | Non-transplant patients | 127 (2 RCTs) | 0.59 | |
79.5 μmol/L | 76.2 μmol/L (MD 2.38 μmol/L lower; 95% CI − 10.98 to 6.23) | |||
Renal transplant patients | 110 (1 RCT) | 0.01 | ||
460 μmol/L | 530 μmol/L (MD 70 μmol/L higher; 95% CI 14.31 to 125.69) | |||
Creatinine—postoperative day 1 | Non-transplant patients | 61 (1 RCT) | 0.44 | |
80 μmol/L | 86 μmol/L (MD 6 μmol/L higher; 95% CI − 21.23 to 9.23) | |||
Renal transplant patients | 150 (2 RCTs) | 0.74 | ||
353.5 μmol/L | 336 μmol/L (MD 12.26 μmol/L lower; 95% CI − 85.10 to 60.57) | |||
Creatinine—postoperative day 3 | Renal transplant patients | 301 (4 RCTs) | 0.98 | |
168 μmol/L | 173 μmol/L (MD 0.47 μmol/L higher; 95% CI − 30.12 to 29.19) | |||