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Table 1 Summary of differences in renal function outcomes between non-buffered and buffered fluid groups

From: Perioperative administration of buffered versus non-buffered crystalloid intravenous fluid to improve outcomes following adult surgical procedures: a Cochrane systematic review

Outcomes Absolute effects No. of participants (studies) p
Outcome with non-buffered fluid (mean) Outcome with buffered fluid (mean; mean difference with 95% CI)
Urine output—intraoperative 799 ml 872 ml (MD 6.1 ml higher; 95% CI − 128.4 to 140.6) 459 (8 RCTs) 0.93
Creatine change—postoperative MD in creatinine was 7.0 μmol/L lower in the buffered fluids group; 95% CI − 27.4 to 13.5 113 (2 RCTs) 0.50
Creatine change—postoperative day 1 MD in creatinine was 4.9 μmol/L lower in the buffered fluids group; 95% CI − 5.9 to 15.8 113 (2 RCTs) 0.37
Creatinine—postoperative Non-transplant patients 127 (2 RCTs) 0.59
79.5 μmol/L 76.2 μmol/L (MD 2.38 μmol/L lower; 95% CI − 10.98 to 6.23)
Renal transplant patients 110 (1 RCT) 0.01
460 μmol/L 530 μmol/L (MD 70 μmol/L higher; 95% CI 14.31 to 125.69)
Creatinine—postoperative day 1 Non-transplant patients 61 (1 RCT) 0.44
80 μmol/L 86 μmol/L (MD 6 μmol/L higher; 95% CI − 21.23 to 9.23)
Renal transplant patients 150 (2 RCTs) 0.74
353.5 μmol/L 336 μmol/L (MD 12.26 μmol/L lower; 95% CI − 85.10 to 60.57)
Creatinine—postoperative day 3 Renal transplant patients 301 (4 RCTs) 0.98
168 μmol/L 173 μmol/L (MD 0.47 μmol/L higher; 95% CI − 30.12 to 29.19)