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Fig. 1 | Perioperative Medicine

Fig. 1

From: The sensitivity of the human thirst response to changes in plasma osmolality: a systematic review

Fig. 1

The pathways initiated by total body water deficit leading to the stimulation of the thirst response. Whilst osmoreceptor stimulation is one of three mechanisms which influence the thirst response, it the most sensitive of these, signalling to the hypothalamus after a 2% reduction in total body water. The convergence of baroreceptor and osmoreceptors onto a shared pathway allows for integration of these distinct physiological parameters, such that thirst increases exponentially with large reductions in extracellular volume

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