From: Preoperative fluid retention increases blood loss during major open abdominal surgery
Parameter | FRI < 3.5 (n = 61) | FRI ≥ 3.5 (n = 36) | Statistics |
---|---|---|---|
Preoperatively | |||
Age (years) | 65 (57–72) | 67 (50–73) | P = 0.59 |
Body weight (kg) | 75 (68–89) | 75 (60–85) | P = 0.42 |
ASA class I/II/III (%)a | 28/59/13 | 38/52/8 | P = 0.48 |
B-Hb concentration (g/l) | 126 (118–134) | 127 (120–135) | P = 0.61 |
U-albumin/creatinine (mg/mmol) | 1.87 (1.15–5.04) | 1.02 (0.65–1.83) | P < 0.002 |
Preoperative fluid experiment (n, %)a | 19 (31%) | 11 (31%) | P = 0.30 |
During surgery | |||
Operating time (h) | 2.3 (1.4–4.1) | 3.3 (2.2–4.2) | P = 0.07 |
Blood loss (ml) | 200 (75–413) | 450 (150–738) | P < 0.01 |
Blood loss/operating time (ml/h) | 87 (41–154) | 123 (74–225) | P < 0.03 |
Erythrocyte transfusion (N patient) | 4 | 5 | |
Erythrocytes transfused (ml) | 863 (552–1408) | 1389 (313–1670) | P = 0.62 |
B-Hb concentration (g/l) | 106 (93–112) | 104 (95–115) | P = 0.76 |
Urine (ml) | 245 (171–500) | 350 (149–500) | P = 0.95 |
Urine/operating time (ml/h) | 92 (62–174) | 96 (48–143) | P = 0.34 |
Crystalloid fluid (ml) | 1081 (688–1430) | 1279 (954–1950) | P = 0.05 |
Colloid fluid (ml) | 1000 (700–1400) | 1430 (953–1956) | P < 0.04 |
Infused fluid volume (ml) | 2140 (1567–2816) | 2594 (2248–3461) | P < 0.02 |
Fluid balance (ml) | + 1506 (1210–2041) | + 1913 (1439–2403) | P < 0.02 |
Fluid balance, blood equivalents (ml) | + 954 (729–1401) | + 1235 (979–1494) | P < 0.03 |
Postoperatively | |||
∆ S-troponin T, day 0 vs. 1–2 (%)b, c | + 20 (0–66) | 0 (− 6 to + 8) | P < 0.02 |
∆ S-NT-proBNP, day 0 vs. 1–2 (%)b, c | + 161 (31–357) | + 150 (41–462) | P = 0.43 |
B-Hb concentration (g/l) | 113 (102–122) | 114 (104–124) | P = 0.74 |
Length of hospital stay (days) | 7 (5–11) | 9 (6–14) | P = 0.15 |