Table 3 Univariate analysis: tier 1 and 2 predictors of C-POMS summary score on D3, D5 and D8
From: Predictors of total morbidity burden on days 3, 5 and 8 after cardiac surgery
Variable | D3 (n = 441) | D5 (n = 419) | D8 (n = 177) | |||
|---|---|---|---|---|---|---|
Median C-POMS/Rho | p | Median C-POMS/Rho | p | Median C-POMS/Rho | p | |
Tier 1 variables | ||||||
Demographics | ||||||
Age | 0.188 | 0.000 | 0.110 | 0.025 | 0.133 | 0.078 |
Age quartiles | ||||||
1 (0–59) | 2.0 | 0.002 | 2.0 | 0.010 | 2.0 | 0.300 |
2 (60–68) | 3.0 | 2.0 | 3.0 | |||
3 (69–74) | 3.0 | 2.0 | 4.0 | |||
4 (≥75) | 4.0 | 2.5 | 3.0 | |||
Age grp 2 | ||||||
<65 | 2.0 | 0.000 | 2.0 | 0.044 | 2.5 | 0.083 |
65–74 | 3.0 | 2.0 | 3.0 | |||
≥75 | 4.0 | 2.5 | 3.0 | |||
Age grp 3 | ||||||
<70 | 3.0 | 0.001 | 2.0 | 0.426 | 3.0 | 0.225 |
70–79 | 3.0 | 2.0 | 3.0 | |||
>80 | 5.0 | 2.0 | 3.0 | |||
Gender | ||||||
M | 3.0 | 0.024 | 2.0 | 0.016 | 3.0 | 0.215 |
F | 3.0 | 3.0 | 2.5 | |||
Medical history | ||||||
Diabetes | ||||||
Y | 4.0 | 0.000 | 2.5 | 0.015 | 3.0 | 0.308 |
N | 3.0 | 2.0 | 3.0 | |||
Cerebrovascular disease | ||||||
Y | 4.0 | 0.028 | 3.0 | 0.023 | 4.0 | 0.219 |
N | 3.0 | 2.0 | 3.0 | |||
Neurological history | ||||||
Y | 4.0 | 0.103 | 3.0 | 0.016 | 4.0 | 0.553 |
N | 3.0 | 2.0 | 3.0 | |||
Congestive heart failure | ||||||
Y | 4.0 | 0.009 | 4.0 | 0.025 | 4.0 | 0.310 |
N | 3.0 | 2.0 | 3.0 | |||
COPD/lung disease | ||||||
Y | 4.0 | 0.005 | 3.0 | 0.012 | 3.0 | 0.380 |
N | 3.0 | 2.0 | 3.0 | |||
Renal disease | ||||||
Y | 5.0 | 0.064 | 5.0 | 0.001 | 5.0 | 0.025 |
N | 3.0 | 2.0 | 3.0 | |||
POSSUM ECG | ||||||
Normal | 3.0 | 0.000 | 2.0 | 0.000 | 3.0 | 0.200 |
Sinus abnormal | 5.0 | 4.0 | – | |||
AF | 4.0 | 3.0 | 3.0 | |||
Any other abnormal | 5.0 | 2.5 | 2.0 | |||
Paced | ||||||
Y | 5.0 | 0.005 | 4.0 | 0.014 | 2.5 | 0.875 |
N | 3.0 | 2.0 | 3.0 | |||
Dialysis | ||||||
Y | 5.5 | 0.073 | 7.5 | 0.006 | 5.5 | 0.064 |
N | 3.0 | 2.0 | 3.0 | |||
Pre-operative measurements | ||||||
Body mass index(kg/m2) | 0.100 | 0.043 | 0.077 | 0.130 | 0.099 | 0.206 |
LVEF | ||||||
Good | 3.0 | 0.013 | 2.0 | 0.011 | 3.0 | 0.013 |
Fair | 3.0 | 2.0 | 4.0 | |||
Poor | 5.0 | 5.0 | 4.0 | |||
Intra-operative | ||||||
Type of surgery | ||||||
CABG | 3.0 | 0.000 | 2.0 | 0.000 | 3.0 | 0.718 |
AVR | 4.0 | 3.0 | 3.0 | |||
MVR | 5.0 | 3.0 | 3.5 | |||
CABG + AVR | 4.0 | 2.0 | 3.0 | |||
AVR + MVR | 3.0 | 3.0 | 4.5 | |||
CABG + MVR + AVR | 5.0 | 5.0 | 6.0 | |||
Other | 5.0 | 3.0 | 3.0 | |||
Urgency of op | ||||||
Elective | 3.0 | 0.002 | 2.0 | 0.061 | 3.0 | 0.327 |
Urgent | 4.0 | 2.0 | 3.0 | |||
Within first 12 h | ||||||
Systolic blood pressure (highest) | 0.002 | 0.959 | 0.026 | 0.599 | −0.089 | 0.238 |
Tier 2 variables | ||||||
Demographics | ||||||
Ethnicity | ||||||
Caucasian | 3.0 | 0.052 | 2.0 | 0.008 | 3.0 | 0.532 |
Asian | 2.0 | 1.0 | 3.0 | |||
Black | 5.0 | 3.0 | 3.0 | |||
Other | 2.0 | 3.0 | 1.0 | |||
Medical history | ||||||
Smoking | ||||||
Current | 2.0 | 0.048 | 2.0 | 0.395 | 3.0 | 0.753 |
Ex | 3.0 | 2.0 | 3.0 | |||
Never | 3.0 | 2.0 | 3.0 | |||
Family Hx CAD | ||||||
Y | 3.0 | 0.002 | 2.0 | 0.019 | 3.0 | 0.686 |
N | 4.0 | 2.0 | 3.0 | |||
Atrial arrhythmia | ||||||
Y | 4.0 | 0.021 | 3.0 | 0.007 | 3.0 | 0.781 |
N | 3.0 | 2.0 | 3.0 | |||
Pre-operative measurements | ||||||
Albumin | −0.210 | 0.000 | −0.144 | 0.004 | −0.183 | 0.019 |
Haemoglobin | −0.279 | 0.000 | −0.180 | 0.000 | −0.143 | 0.058 |
Heart rate | 0.090 | 0.058 | 0.179 | 0.000 | 0.080 | 0.294 |
Weight | 0.044 | 0.369 | 0.042 | 0.399 | 0.101 | 0.186 |
No diseased vessels | ||||||
0 | 4.0 | 0.011 | 3.0 | 0.000 | 3.0 | 0.203 |
1 | 3.0 | 2.0 | 2.0 | |||
2 | 3.0 | 2.0 | 2.0 | |||
3 | 3.0 | 2.0 | 3.0 | |||
NYHA class | ||||||
1 | 2.0 | 0.001 | 1.0 | 0.002 | 3.0 | 0.001 |
2 | 3.0 | 2.0 | 3.0 | |||
3 | 4.0 | 3.0 | 3.0 | |||
4 | 5.0 | 2.5 | 5.0 | |||
CCSC class | ||||||
0 | 3.0 | 0.041 | 3.0 | 0.042 | 3.0 | 0.317 |
1 | 2.0 | 2.0 | 2.0 | |||
2 | 3.0 | 2.0 | 3.0 | |||
3 | 3.0 | 2.0 | 3.0 | |||
4 | 4.0 | 2.0 | 4.0 | |||
Cardiomegaly | ||||||
Y | 5.0 | 0.000 | 3.0 | 0.000 | 4.0 | 0.141 |
N | 3.0 | 3.0 | 3.0 | |||
Not stated | 3.0 | 3.0 | 3.0 | |||
Extracardiacarteriopathy | ||||||
Y | 5.0 | 0.003 | 3.0 | 0.004 | 4.5 | 0.147 |
N | 3.0 | 2.0 | 3.0 | |||
Current medications | ||||||
Diuretic | ||||||
Y | 4.0 | 0.003 | 3.0 | 0.003 | 3.0 | 0.780 |
N | 3.0 | 2.0 | 3.0 | |||
Intra-operative | ||||||
Cardiopulmonary bypass | ||||||
Y | 3.0 | 0.001 | 2.0 | 0.072 | 3.0 | 0.098 |
N | 2.0 | 1.0 | 1.0 | |||
Within 1st 12 h after surgery | ||||||
Total drainage | 0.139 | 0.004 | 0.030 | 0.542 | 0.031 | 0.679 |
Post-operative (D1) | ||||||
Heart rhythm | ||||||
Sinus rhythm | 3.0 | 0.000 | 2.0 | 0.002 | 3.0 | 0.473 |
Sinus tachycardia | 2.5 | 2.0 | 2.5 | |||
Sinus bradycardia | 4.0 | 2.0 | 4.0 | |||
Atrial fibrillation | 5.0 | 3.0 | 4.0 | |||
Other | 3.0 | 2.0 | 3.0 | |||
Inotropes | ||||||
Y | 4.0 | 0.004 | 3.0 | 0.070 | 3.0 | 0.923 |
N | 3.0 | 2.0 | 3.0 | |||