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Table 2 Descriptive data and statistics

From: Coagulation during elective neurosurgery with hydroxyethyl starch fluid therapy: an observational study with thromboelastometry, fibrinogen and factor XIII

 

Reference interval

Baseline

After 1 L HES (patients receiving ≥1 L HES)

P value

End of surgery

P value

Morning after surgery

P value

Baseline vs after 1 L HES (patients receiving ≥1 L HES)

Baseline vs end of surgery

Baseline vs morning after surgery

Analysed in all patients (n = 40)

 CT (s)

38–79

50.5 (36–121)

63 (37–125)

<0.0001

57 (38–101) [3]

0.027

54 (36–97) [5]

0.41

 CFT (s)

34–159

110.5 (64–286)

170 (97–325)

<0.0001

135 (74–311) [3]

<0.0001

116 (57–276) [5]

0.13

 Alpha angle (°)

63–83

68 (51–80)

58 (48–70)

<0.0001

64 (46–75) [3]

<0.0001

68 (45–79) [5]

0.034

 MCF (mm)

50–72

59 (39–69)

50 (38–74)

<0.0001

55 (38–65) [3]

<0.0001

58 (46–69) [6]

0.24

 FIBTEM-MCF (mm)

9–25

12 (4–24)

7 (0–12)

<0.0001

9 (2–18) [5]

<0.0001

14 (5–26) [5]

0.051

 Fibrinogen (g/L)

2–4

1.9 (0.9–3.3)

1.4 (0.6–2.8)

<0.0001

1.5 (0.6–2.8)

<0.0001

2.4 (0.6–3.4) [5]

0.012

Analysed in patients receiving ≥1000 mL HES (n = 25)

 FXIII (kIU/L)

0.7–1.4

0.9 (0.43–>1.30)

0.62 (0.32–1.16)

<0.0001

0.68 (0.39–1.19) [3]

<0.0001

0.84 (0.44–>1.30) [3]

<0.0001

 TAT (μg/L)

1.0–4.1

4.4 (2–68) [1]

7.2 (2–98)

0.0087

23.4 (2–142) [3]

0.0004

8.1 (3–449) [2]

0.0032

 PAP (μg/L)

120–700

541.3 (275–1997)

419.5 (218–1478)

<0.0001

392.4 (276–1339) [3]

<0.0001

481.0 (288–2297) [2]

0.80

  1. Data is presented as median values (range) [missing]. Italicized P values are statistically significant (P < 0.0083)
  2. HES hydroxyethyl starch, CT clotting time, CFT clot formation time, MCF maximum clot firmness, TAT thrombin-antithrombin complex, PAP plasmin-α2-antiplasmin complex, FXIII factor XIII