| |
Reference interval
|
Baseline
|
After 1 L HES (patients receiving ≥1 L HES)
|
P value
|
End of surgery
|
P value
|
Morning after surgery
|
P value
|
|---|
|
Baseline vs after 1 L HES (patients receiving ≥1 L HES)
|
Baseline vs end of surgery
|
Baseline vs morning after surgery
|
|---|
|
Analysed in all patients (n = 40)
|
|
CT (s)
|
38–79
|
50.5 (36–121)
|
63 (37–125)
|
<0.0001
|
57 (38–101) [3]
|
0.027
|
54 (36–97) [5]
|
0.41
|
|
CFT (s)
|
34–159
|
110.5 (64–286)
|
170 (97–325)
|
<0.0001
|
135 (74–311) [3]
|
<0.0001
|
116 (57–276) [5]
|
0.13
|
|
Alpha angle (°)
|
63–83
|
68 (51–80)
|
58 (48–70)
|
<0.0001
|
64 (46–75) [3]
|
<0.0001
|
68 (45–79) [5]
|
0.034
|
|
MCF (mm)
|
50–72
|
59 (39–69)
|
50 (38–74)
|
<0.0001
|
55 (38–65) [3]
|
<0.0001
|
58 (46–69) [6]
|
0.24
|
|
FIBTEM-MCF (mm)
|
9–25
|
12 (4–24)
|
7 (0–12)
|
<0.0001
|
9 (2–18) [5]
|
<0.0001
|
14 (5–26) [5]
|
0.051
|
|
Fibrinogen (g/L)
|
2–4
|
1.9 (0.9–3.3)
|
1.4 (0.6–2.8)
|
<0.0001
|
1.5 (0.6–2.8)
|
<0.0001
|
2.4 (0.6–3.4) [5]
|
0.012
|
|
Analysed in patients receiving ≥1000 mL HES (n = 25)
|
|
FXIII (kIU/L)
|
0.7–1.4
|
0.9 (0.43–>1.30)
|
0.62 (0.32–1.16)
|
<0.0001
|
0.68 (0.39–1.19) [3]
|
<0.0001
|
0.84 (0.44–>1.30) [3]
|
<0.0001
|
|
TAT (μg/L)
|
1.0–4.1
|
4.4 (2–68) [1]
|
7.2 (2–98)
|
0.0087
|
23.4 (2–142) [3]
|
0.0004
|
8.1 (3–449) [2]
|
0.0032
|
|
PAP (μg/L)
|
120–700
|
541.3 (275–1997)
|
419.5 (218–1478)
|
<0.0001
|
392.4 (276–1339) [3]
|
<0.0001
|
481.0 (288–2297) [2]
|
0.80
|
- Data is presented as median values (range) [missing]. Italicized P values are statistically significant (P < 0.0083)
-
HES hydroxyethyl starch, CT clotting time, CFT clot formation time, MCF maximum clot firmness, TAT thrombin-antithrombin complex, PAP plasmin-α2-antiplasmin complex, FXIII factor XIII
