Skip to main content

Table 2 Summary of gentamicin and vancomycin pharmacokinetic parameters in all cohorts

From: A randomized, double-blind, placebo controlled safety, tolerability, and pharmacokinetic dose escalation study of a gentamicin vancomycin gel in patients undergoing colorectal surgery

Characteristic

Actual dosea

T max

C max

AUC(0–t)

t 1/2

(mg)

(h)

(mcg/mL)

(mcg h/mL)

(h)

Gentamicin

     

  n

24

24

24

24

18

 Mean (SD)

149 (75.9)

6.01 (3.48)

0.642 (0.524)

14.2 (12.6)

17.7 (4.98)

Vancomycin

     

  n=

24

21

24

24

0

 Mean (SD)

167 (84.9)

22.2 (18.7)

0.164 (0.150)

6.47 (8.12)

NC

  1. AUC area under the curve, C max, maximum concentration, h hour, mcg microgram, mg milligram, mL milliliter, N number, NC not calculated, SD standard deviation, t ½ half-life
  2. aMean amount of drug retained for all cohorts 8.9 ± 4.52 mL
Back to article page

Perioperative Medicine

ISSN: 2047-0525