Table 1 Patient and procedure characteristics and study drug administration

Age, years

56.5 (45.1,60.6)

70.9 (63.2, 76.3)

46.9 (41.4, 61.2)

Gender, % male

2 (33.3 %)

6 (37.5 %)

4 (50 %)

Race, % white

5 (83.3 %)

14 (87.5 %)

7 (87.5 %)

Weight, kg

74.7 (72.3,76.4)

90.9 (72.3,97.1)

81.8 (73.3, 97.5)

Height, cm

164.3 (157.5, 175.2)

167.6 (158.7, 175.3)

171.4 (165.1, 180.4)

Body mass index (kg/m²)

28.2 (27.0, 29.9)

29.1 (27.8, 33.9)

28.2 (25.7, 30.6)

Preoperative serum creatinine (mg/dL)

0.7 (0.7, 0.9)

0.9 (0.8, 1.3)

0.9 (0.8, 1.0)

Duration of surgical procedure (h)

2.8 (1.4, 4.6)

2.0 (1.1, 2.3)

3.0 (2.4, 5.6)

Length of incision (cm)

11.3 (8.0, 26.0)

8.2 (7.8, 10.0)

8.5 (7.8, 10.5)

Depth of incision at midpoint (cm)

2.2 (1.5, 3.0)

2.5 (1.5, 3.3)

2.5 (2.0, 3.0)

Wound area (cm²)

45.7 (11.1, 79.7)

22.3 (12.1, 30.0)

22.8 (18.0, 32.3)

Study drug volume inserted into wound (mL)

19.0 (10.0, 20.0)

10.0 (10.0, 20.0)

25.0 (20.0, 30.0)

Overflow study drug collected (mL)

4.5 (3.0, 7.0)

5.0 (1.5, 12.5)

12.0 (6.0, 15.0)

Volume of study drug retained in wound (mL)

9.5 (5.0, 17.0)

5.0 (4.5, 9.8)

15.0 (12.5, 15.5)

Volume of study drug per wound area (mL/cm²)

0.2 (0.2, 0.5)

0.3 (0.2, 0.4)

0.6 (0.5, 0.7)