Skip to main content

Advertisement

Table 1 Summary of sample sizes, population, regime, and outcomes

From: A systematic review and meta-analysis of perioperative oral decontamination in patients undergoing major elective surgery

Author Location Patients (chlorhexidine vs. control) Population Chlorhexidine strength Regime Overall nosocomial infection Postoperative pneumonia Mortality
De Riso 1996 USA 353 (173 vs. 180) Cardiac 0.12 % Preop (no time scale given) and postop (discharge from ITU or death). Mean = 8.2 days 8/173 (4.6 %)
24/180 (13.3 %)
5/173 (2.9 %)
17/180 (9.4 %)
3/173 (1.7 %)
10/180 (5.6 %)
Houston et al 2002 USA 561 (270 vs. 291) Cardiac 0.12 % Preop (no time scale given) and postop (10 days or extubation, tracheostomy, development of POP or death) 4/270 (1.5 %)
9/291 (3.1 %)
6/270 (2.2 %)
3/291 (1 %)
Nicolosi et al 2014 Argentina 300 (150 vs. 150) Cardiac 0.12 % Preop (3 days) 46/150 (30.7 %)
69/150 (46 %)
4/150 (2.7 %)
13/150 (8.7 %)
8/150 (5.3 %)
7/150 (4.7 %)
Segers et al. 2006 USA 991 (500 vs. 491) Cardiac 0.12 % Preop (mean = 1.9 days) and postop (no time scale given) 116/500 (23.2 %)
164/491 (33.4 %)
45/500 (9 %)
74/491 (15.1 %)
8/500 (1.6 %)
6/491 (1.2 %)