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Table 1 Data on the groups used for the simulations. The results are given as the mean (SD)

From: How fast can glucose be infused in the perioperative setting?

Study group Experiments (N) Age (years) Body weight (kg) Female/males Glucose load (g/kg) Plasma glucose baseline (mmol/l) Plasma insulin baseline (pmol/l) 10log HOMA-IRa V d/BW (ml/kg) CL/BW (ml/(kg min)) Half-lifeb (min) Reference
Healthy volunteers 44 29 (7) 73 (14) 8/18c 0.25–0.62 5.0 (0.4) 35 (23) 2.15 (0.33) 164 (74) 8.7 (3.4) 15 (8) Sjöstrand and Hahn (2003); Hahn et al. (2011)
1 day before hip replacement surgery 82 68 (9) 82 (15) 54/28 0.20–0.30 5.2 (0.7) 62 (50) 2.38 (0.35) 164 (29) 4.7 (1.8) 28 (11) Hahn et al. (2013); Ljunggren and Hahn (2012)
During hernia surgery 9 37 (16) 80 (11) 0/9 ≈0.20 5.7 (0.4) 152 (24) 1.6 (0.3) 66 (13) Sicardi Salomón et al. (2006)d
During laparoscopic cholecystectomy 20 40 (8) 75 (10) 14/6 0.25–0.47 5.0 (0.6) 45 (26) 2.29 (0.25) 121 (19) 2.8 (0.7) 33 (12) Sjöstrand and Hahn (2004); Sicardi Salomón et al. (2006)d
During open abdominal surgery 9 69 (6) 63 (11) 4/5 ≈0.20 5.7 (1.1) 190 (34) 1.5 (0.7) 110 (67) Sicardi Salomón et al. (2006)d
2–3 h after hip replacement surgery 60 68 (9) 83 (15) 41/9 0.20 5.9 (1.1) 47 (28) 2.35 (0.34) 174 (34) 3.3 (0.9) 38 (11) Ljunggren and Hahn (2012)
1 day after hip replacement surgery 82 68 (9) 82 (15) 41/19 0.20–0.30 6.3 (0.8) 66 (44) 2.55 (0.27) 170 (31) 3.7 (1.3) 35 (13) Hahn et al. (2013); Ljunggren and Hahn (2012)
2 days after hysterectomy 15 50 (5) 70 (9) 15/0 0.31 6.2 (0.7) 35 (16) 2.28 (0.25) 147 (41) 6.1 (1.2) 17 (5) Strandberg and Hahn (2005)
  1. aThe 10log of (P-glucose × P-insulin). For crude HOMA-IR, the product should be divided by 156 to correct for units (22.5 if insulin is reported in mU l−1) where 1 = normal
  2. bThe half-life was obtained as 0.693 V d/CL
  3. cSix males underwent four experiments each
  4. dThe study divided the kinetics into infusion and postinfusion phase. The kinetics from the infusion was used here