Table 1 Data on the groups used for the simulations. The results are given as the mean (SD)
From: How fast can glucose be infused in the perioperative setting?
Study group | Experiments (N) | Age (years) | Body weight (kg) | Female/males | Glucose load (g/kg) | Plasma glucose baseline (mmol/l) | Plasma insulin baseline (pmol/l) | 10log HOMA-IRa | V d/BW (ml/kg) | CL/BW (ml/(kg min)) | Half-lifeb (min) | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Healthy volunteers | 44 | 29 (7) | 73 (14) | 8/18c | 0.25–0.62 | 5.0 (0.4) | 35 (23) | 2.15 (0.33) | 164 (74) | 8.7 (3.4) | 15 (8) | |
1 day before hip replacement surgery | 82 | 68 (9) | 82 (15) | 54/28 | 0.20–0.30 | 5.2 (0.7) | 62 (50) | 2.38 (0.35) | 164 (29) | 4.7 (1.8) | 28 (11) | |
During hernia surgery | 9 | 37 (16) | 80 (11) | 0/9 | ≈0.20 | 5.7 (0.4) | – | – | 152 (24) | 1.6 (0.3) | 66 (13) | Sicardi Salomón et al. (2006)d |
During laparoscopic cholecystectomy | 20 | 40 (8) | 75 (10) | 14/6 | 0.25–0.47 | 5.0 (0.6) | 45 (26) | 2.29 (0.25) | 121 (19) | 2.8 (0.7) | 33 (12) | |
During open abdominal surgery | 9 | 69 (6) | 63 (11) | 4/5 | ≈0.20 | 5.7 (1.1) | – | – | 190 (34) | 1.5 (0.7) | 110 (67) | Sicardi Salomón et al. (2006)d |
2–3 h after hip replacement surgery | 60 | 68 (9) | 83 (15) | 41/9 | 0.20 | 5.9 (1.1) | 47 (28) | 2.35 (0.34) | 174 (34) | 3.3 (0.9) | 38 (11) | Ljunggren and Hahn (2012) |
1 day after hip replacement surgery | 82 | 68 (9) | 82 (15) | 41/19 | 0.20–0.30 | 6.3 (0.8) | 66 (44) | 2.55 (0.27) | 170 (31) | 3.7 (1.3) | 35 (13) | |
2 days after hysterectomy | 15 | 50 (5) | 70 (9) | 15/0 | 0.31 | 6.2 (0.7) | 35 (16) | 2.28 (0.25) | 147 (41) | 6.1 (1.2) | 17 (5) | Strandberg and Hahn (2005) |