Functional volumes in a two-fluid space model. R0 is the infusion rate in mL/min, V
is the central fluid space, v
is the expanded central fluid space in liters, V
is the peripheral fluid space, v
is the expanded peripheral space in liters, Cl0 is the basal elimination in mL/min, Cld is the interfluid space constant in mL/min and Cl is the dilution dependent elimination in mL/min.