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Table 6 Univariate and multivariate analysis of pre- and intra-operative factors associated with serum lactate concentration following liver resection in 488 patients

From: Serum arterial lactate concentration predicts mortality and organ dysfunction following liver resection

N = 488   Univariate analysis Multivariate analysis
Factor   P value Co-ef +/− SD P value
Age   0.246*   0.925
Gender   0.012*   0.129
Pathology Benign vs. Primary 0.442   0.144
  Primary vs. Secondary 0.226*   0.878
Liver-directed chemotherapy   0.129*   0.219
Open or laparoscopic resection   0.009*   0.611
Radiofrequency ablation   0.191*   0.402
Wedge resection included   <0.001*   0.086
Bile duct reconstruction   0.004*   0.651
Number of segments resected   <0.001* 0.143 ± 0.012 <0.001†
Synchronous bowel procedure   0.516   
Surgeon’s assessment of liver   <0.001* 0.185 ± 0.042 <0.001†
Redo operation 1st vs. 2nd resection 0.268   
  2nd vs. 3rd resection 0.654   
Pre-operative diabetes   <0.001* 0.204 ± 0.064 0.002†
Body mass index   0.06*   0.905
ASA grade 1 vs. 2 0.014*   0.824
  2 vs. 3 0.709   0.872
P-POSSUM physiologic score   0.054*   0.221
Hepatic fibrosis/cirrhosis   0.667   
Pre-operative bilirubin   0.320   
Pre-operative haemoglobin   0.633   
Neutrophil:lymphocyte ratio   0.400   
Pre-operative albumin   0.399   
Pre-operative alkaline phosphatase   0.014*   0.775
Pre-operative creatinine   0.392   
Pre-operative glomerular filtration rate (GFR) >90 ml/min   0.042*   0.054
Blood loss (ml) <500 vs. 500-999 <0.001* 0.131 ± 0.038 0.013†
  500-999 vs. >1000 0.435   0.884
Units of red cells transfused   <0.001* 0.043 ± 0.011 <0.001†
  1. *Significant at the level of 0.25 for univariate analysis and included in multivariate analysis; †significant at the level of 0.05 for multivariate analysis.