Incidence and characteristic analysis of in-hospital falls after anesthesia
© Lam et al. 2016
Received: 29 January 2016
Accepted: 9 May 2016
Published: 23 May 2016
In-hospital falls may result in serious clinical adverse consequences, but the effects of anesthesia in the occurrence of postoperative falls are still undetermined. Anesthesia may theoretically cause postoperative falls due to the residual pharmacologic and neuromuscular blocking effects of anesthetics. We retrospectively reviewed events of in-hospital falls occurred after anesthesia management to identify the incidence and risk factors of postanesthesia falls.
We reviewed the postanesthesia visit of patients received anesthesia in the Hualien Buddhist Tzu Chi General Hospital from January 2009 to December 2013. Falls happened within 24 h after anesthesia were recorded. The Poisson regression model was used for simultaneous analysis of the association between incidence proportion of postanesthesia falls and the potential risk factors.
A total of 60,796 inpatients received anesthesia management over the past 5 years, and ten patients fell within 24 h after anesthesia. All cases happened in the general wards. Falls occurred more often at the bedside, presence of caregivers, and during the daytime. Patients underwent regional anesthesia, and old age significantly increased the risk of postanesthesia falls, while differences in gender and ASA physical status did not affect the occurrence of postanesthesia falls.
The overall incidence proportion of postanesthesia falls is 1.6 cases per 10,000 patients (95 % CI 0.006 to 0.026 %) over a 24-h observation period. Falls are more commonly happened during the less expected periods after operation and are increased in the elderly and patients received regional anesthesia. This study highlights that more comprehensive clinical practice guidelines for postoperative care should be exercised to prevent the in-hospital falls.
KeywordsAccidental falls Poisson distribution Postoperative complications Regional anesthesia
Postoperative falls are a relatively rare complication that could have been overlooked in clinical anesthesia. In-hospital falls are particularly serious events resulting in bone fracture, traumatic head injury, visceral organ contusion, and skin abrasion. These in-hospital adverse events not only increase the length of hospital stay and cause extraneous medical expense but may also engender unnecessary medical disputes (Bates et al. 1995; Mion et al. 2012). Therefore, the implementation of preventive strategies for in-hospital falls has been an important practical issue in the hospital care (Hempel et al. 2013). However, the investigation of the in-hospital falls during the postoperative period is insufficient (Amador and Loera 2007; Church et al. 2011). The overall incidence of postoperative falls was 1.6–1.8 % in a veteran’s medical center with an average time to falling of 12 days after operation (Church et al. 2011). The incidence of postoperative falls may theoretically increase in patients receiving anesthetic management due to the residual pharmacologic and neuromuscular blocking effects of anesthetics. However, the anesthetic effect on the postoperative falls is hard to identify from these previous studies, and there is currently no study reported the incidence of postanesthesia falls. Therefore, we retrospectively reviewed the postanesthesia records (2009 to 2013) in our department and analyzed the characteristics of in-hospital falls after anesthesia management. Our long-term aim is to identify the risk factors contributing to falls during the postanesthesia period and to promote prevention programs in the surgical patients who carry high risk of in-hospital falls.
Patient database and study design
This retrospective chart-review study was approved by the ethics committee and the institutional review board (IRB, Approval number IRB103-14-B) of Hualien Buddhist Tzu Chi General Hospital Taiwan, and the requirement for written informed consent was waived by the ethics committee. Our hospital is a tertiary teaching medical center located at Hualien City of Taiwan that consists of 945 beds. In-hospital patients, who received anesthesia management for surgical or other medical interventions from January 2009 to December 2013, were visited at bedside postoperatively by nurse anesthetists. The postoperative visit recorded the pain scores, patient satisfaction to anesthesia service, and anesthesia-related complications. All adverse events after operation recorded by the ward nurses were reviewed. Falls were defined as sudden events which resulted in a person coming to rest inadvertently on the ground or floor or other lower levels (Haines et al. 2013). The medical records of all patients reported of having in-hospital falls within 24 h after operation were reviewed by the staff anesthesiologists to determine the characteristics of falls. Patients who received only regional infiltration of local anesthetics and who were discharged from hospital within 24 h after operation were excluded.
The overall incidence proportion of postanesthesia falls over a 24-h observation period was calculated as the number of falls divided by total number of in-hospital surgical patients who received anesthesia management. The potential risk factors included patient demographic and clinical variables, namely patient age groups, genders, American Society of Anesthesiologists (ASA) classifications of physical status, and types of anesthesia. Poisson regression model was adopted to evaluate the association between these risk factors and postanesthesia falls. The model fitted reasonably well as the goodness-of-fit chi-squared test was not statistically significant (p = 0.995). Statistical significance was accepted at a level of P < 0.05. All statistical analyses were performed by using SAS 9.4 (SAS Institute, Inc., Cary, North Carolina).
Demographic characteristics of patients received anesthesia management during January 2009 to December 2013 (n = 78,064)
Age (years old)
Type of anesthesia
Intravenous sedation anesthesia
Regional and other anesthesia techniques
Admission after operation
Intensive care units
Discharged from recovery room
Completion of postoperative visits (in-hospital)
Characteristics of postanesthesia falls
Type of surgery
Type of anesthesia
Injury after fall
Hours after anesthesia
Debridement of hip wound
Admitted to ICU
LMA + NB
Characteristics of postanesthesia falls
Characteristics of fall events
Time of fall
Place of fall
Presence of accompany
Attempts of getting off bed
Risk stratification for postanesthesia falls
All patients (total 78,064) n (%)
In-hospital patients (total 60,796) n (%)
Postanesthesia falls (total 10) n (%)
Age (years old)
Types of anesthesia
Intravenous sedation anesthesia
Regional and other anesthesia techniques
Poisson regression analysis of the risk factors in the occurrence of postanesthesia falls
95 % CI
≦30 years old
31–50 years old
51–70 years old
>70 years old
Intravenous sedation anesthesia
We present the first clinical report analyzing the incidence and risk factors of in-hospital falls within 24 h after anesthesia management. The overall incidence proportion of postanesthesia falls was at least 1.6 cases per 10,000 patients over a 24-h observation period. Patients with older age and who received regional anesthesia or intravenous sedation anesthesia carried significantly higher incidence proportion of postanesthesia falls. Falls happened more often during the relatively less expected periods and locations after operation, such as at the bedside, presence of caregivers, and during the daytime. Although most of these events did not result in serious consequences, there were considerable proportions of patients (30 %) who required additional medical or surgical attentions.
Successful surgical and anesthesia managements do not necessarily guarantee the avoidance of postoperative complications or adverse events. Therefore, several preoperative risk assessment systems have been developed to reduce the occurrence of postoperative adverse events (Barnett and Moonesinghe 2011; Hariharan and Zbar 2006). However, the identification of the incidence and risk factors of the rare adverse events is more challenging, as the conduction of prospective clinical studies is impractical and could be insensitive to detect the low incidence events. Therefore, the access to a comprehensive medical record of postoperative visit may be an acceptable alternative to prospective trials in the identification of the rare postoperative adverse events.
Postoperative falls are one of the relatively rare complications that could have been overlooked in clinical practice. There is currently very limited information in the study and prevention programs for postoperative falls (Church et al. 2011). Church et al. conducted a comprehensive retrospective study analyzing the occurrence of postoperative falls in patients admitted to a tertiary Veteran hospital for more than 23 h after surgery (Church et al. 2011). They reported that 154 male patients experienced 190 falls in a total of 9625 inpatient surgical procedures over the 5-year study period, thereby yielding an overall incidence of postoperative falls of 1.6 %. The authors found that older age, ASA class > III, low albumin level, longer surgical time, and increased blood transfusion were the independent risk factors for postoperative falls. Nevertheless, the effects of anesthesia on the occurrence of postoperative falls are still undetermined and are unable to generalize from these previous studies.
The Hualien Buddhist Tzu Chi General Hospital is a tertiary university hospital and admits all patient populations. The in-hospital postanesthesia visit recorded the anesthetic outcomes and complications detected within 24 h after anesthesia, with an average annual conclusion rate of greater than 97 % in 2009 to 2013. Therefore, the postanesthesia visiting records in our department may provide a reliable database for the analysis of the in-hospital adverse events that happened after anesthesia in the general population. All postoperative adverse events were reported by the ward nurses and our nurse anesthetists recorded the events occurred within 24 h after anesthesia, as the pharmacologic effects of anesthetic agents are theoretically diminished and most of the patients are recovered from the neuromuscular block.
A total of ten events of postanesthesia falls were recorded from 60,796 in-hospital anesthesia procedures during the 5-year study period. The incidence proportion of falls after operation was considerably less than that reported by Church et al. (0.016 vs 1.6 %). Obviously, the observational period of the later was longer (24 h vs 30 days postoperatively) and the later recruited surgical patients who received only local anesthesia. Contrarily, postanesthesia falls developed within 24 h after anesthesia resulted in much more serious injuries that required surgical or medical interventions (30 vs 0.3 %). These serious complications included traumatic head injury, bone fracture and ICU admission, and thus lengthening the in-hospital treatment course. Head-to-head comparison of the severity of outcomes after falling between these two studies is infeasible, since the studied populations and anesthetic interventions were incommensurable. In our opinion, the residual anesthetic and neuromuscular blocking effects might have contributed to the more severe adverse clinical outcomes in patients with postanesthesia falls.
Our study outlined a few extraordinary findings in the occurrence of falls after anesthesia. More postanesthesia falls happened during at the bedside, with the presence of caregivers and after the first uneventful getting off the bed. Consistent with a most recent study (Ikutomo et al. 2015), our study also found that in-hospital falls were often reported during daytime. Patients and the accompanists could become less cautious when the patients moved about in these situations, as these are generally considered as safer scenarios during postoperative care. In addition, we also found that all events of postanesthesia falls occurred at general wards, but not in other special care units, since patients admitted to these units are more seriously ill and are mostly confined to bed after operation. Although these characteristic analyses of falls are descriptive and statistical analysis is not applicable, our study underscores that the preventive strategy for postanesthesia falls should also be comprised to all postoperative periods during the inpatient care (Ikutomo et al. 2015).
We identified four potential independent risk factors for the development of postanesthesia falls from the postanesthesia visit records, namely gender, age, ASA classification, and types of anesthesia techniques. Advanced age has been widely recognized as an independent risk factor for inpatient falls (Marschollek et al. 2012; Oliver et al. 2010). In traumatic patients, male gender is associated with high incidence of in-hospital falls (Brown et al. 2013). The ASA classification is a useful functional assessment tool for the physical status of surgical patients. Higher ASA classes predict the occurrence of falls in the postoperative periods (Church et al. 2011). These common reported factors were included in our analysis. In comparison to subpopulation groups (i.e., trauma and veteran patients) (Church et al. 2011; Brown et al. 2013), our study in the general patient population did not suggest that differences in gender and ASA classification affect the occurrence of falls within 24 h after anesthesia. In our hospital, patients with advanced ASA classes (≥III) were more often admitted to the special medical units for intensive postoperative care and thus might reduce the potential risk of falling during the first postoperative day. Nevertheless, we admit that patients with impaired physical status (high ASA classes) are conceivably more vulnerable to falling in the subsequent hospital care after operation (>24 h). Consistent with the previous reports, our investigation indicated that the incidence proportion of postanesthesia falling is significantly increased in patients with older age (mean age of 65 ± 15 years). Patients of older ages are more susceptible to falls due to multiple interacting intrinsic and extrinsic etiologies, such as comorbidity diseases, postural hypotension, muscle weakness, impaired gait, and presence of environmental hazards in hospital (Rubenstein 2006; Gschwind et al. 2011).
The core objective of this study is to determine the impact of anesthesia in the development of falls after surgical or other invasive interventions in the general population. Poisson statistical analysis clearly indicates that types of anesthesia significantly affect the occurrence of in-hospital falls within 24 h after anesthesia management. Incidence proportion of postanesthesia falls was significantly increased in patients who received neuroaxial block. Although neuroaxial blockade does not seem to impair the balance control (Suarez and Macadar 2008), the recovery of sensory and muscle power is usually unpredictable and the unassisted ambulation is longer than it is assumed (Imarengiaye et al. 2003). Furthermore, the motor and functional recoveries are variable between individual subjects following intrathecal administration of different local anesthetics (Frey et al. 1998). In clinical practice, we recommend that patient ambulation should only be allowed 8 h after regional block, and we do not routinely check the recovery profiles of patients after discharged from the recovery room. Therefore, it could be the main reason that patients might undertake unassisted ambulation without recognizing the incomplete recovery of muscle power of the lower extremities, and thus resulted in falling. We also realize that the three patients who fell after spinal anesthesia were even older (52, 76, and 92 years) than the mean age of all other falling cases (62 years). Furthermore, there was a postoperative fall patient received inhalational anesthesia via laryngeal mask for knee replacement surgery, and single injection of femoral nerve block was applied as an adjunct for perioperative pain management. Although the sample size is too small to draw any conclusive statements, our results are consistent with the previous reports that suggested that regional nerve blockade in older patients could further increase the risk of postoperative falls (Wasserstein et al. 2013). Administration of peripheral nerve block in knee operation has been reported to increase the risk of postoperative falls (Muraskin et al. 2007; Sharma et al. 2010), particularly with the application of continuous lumbar plexus blockade (Johnson et al. 2013). Therefore, any pharmacologic inhibition of nerve conduction in lower extremities following central or peripheral nerve blockade could contribute to the increased risk of postoperative falls. In addition, we detected a significant increased incidence proportion of postoperative falls in patients who received intravenous sedation anesthesia for less invasive procedures, such as endoscopic examination and simple hemorrhoidectomy. These three patients who received intravenous anesthesia were generally less seriously ill (ASA class II-III), and falls happened within 4 h after anesthesia. The reasons for postanesthesia falls in patients received sedation anesthesia are unclear, but these fall events could probably be preventable if higher attention was applied to the postoperative period, even though the anesthesia management was less invasive.
Limitations of the study
There are several limitations in our study. This is a retrospective case-series chart-review study, and it could therefore be subjected to incomplete collection of all cases throughout the studied period. However, we admit that in-hospital falls has been an imperative monitoring parameter of health care quality assurance in our hospital. Therefore, missing of case record is most unlikely to happen. In addition, prevention of in-hospital falls has been one of the most important medical care issues in our hospital, as the “anti-falling partition board” was established by the medical and nursing staff in 2005. The occurrence of falling has thus significantly reduced after the application of fall prevention programs. Following the introduction of laryngeal mask airway, the use of regional anesthesia has reduced in our hospital due to the improved safety profile with general anesthesia. As a result, the total number of regional anesthesia in our hospital is relatively lower than other institutes. Our postanesthesia visit recorded only the identifications of the patients and did not contain patients’ laboratory data and the perioperative medicine. Hence, we were not able to demonstrate the potential effects of these factors in the occurrence of in-hospital falls after anesthesia. Nevertheless, gender, age, ASA class, and anesthesia techniques are the four most indispensable patient demographical data that should be available in the record of all institutes worldwide. We address that these simple, but basic parameters, may provide useful information in the identification of the high-risk groups of postanesthesia falls.
The overall incidence proportion of postanesthesia falls is at least 1.6 cases per 10,000 patients over a 24-h observation period. Falls are more commonly happened during the less expected periods after operation and are increased in the elderly and patients who received regional anesthesia. This study highlights that more comprehensive clinical practice guidelines for postoperative care should be exercised to prevent the in-hospital falls.
American Society of Anesthesiologists
institutional review board
This work was supported by research funds from the Buddhist Tzu Chi General Hospital (grant numbers TCRD104-27 to C.F.L. and TCRD104-26 to T.Y.C.).
CF contributed to the study conception, study design, data analysis, and writing the article. SY, HS, and XZ carried out the data collection and clinical case analysis. JH performed the data analysis and interpretation. YC contributed to the data analysis and critical revision of the article. TY conceived the study and participated in its design and coordination. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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- Amador LF, Loera JA. Preventing postoperative falls in the older adult. J Am Coll Surg. 2007;204:447–52.View ArticlePubMedGoogle Scholar
- Barnett S, Moonesinghe SR. Clinical risk scores to guide perioperative management. Postgrad Med J. 2011;87:535–41.View ArticlePubMedGoogle Scholar
- Bates DW, Pruess K, Souney P, Platt R. Serious falls in hospitalized patients: correlates and resource utilization. Am J Med. 1995;99:137–43.View ArticlePubMedGoogle Scholar
- Brown CV, Ali S, Fairly R, Lai BK, Arthrell J, Walker M, Tips G. Risk factors for falls among hospitalized trauma patients. Ann Surg. 2013;79:465–9.Google Scholar
- Church S, Robinson TN, Angles EM, Tran ZV, Wallace JI. Postoperative falls in the acute hospital setting: characteristics, risk factors, and outcomes in males. Am J Surg. 2011;201:197–202.View ArticlePubMedGoogle Scholar
- Frey K, Holman S, Mikat-Stevens M, Vazquez J, White L, Pedicini E, Sheikh T, Kao TC, Kleinman B, Stevens RA. The recovery profile of hyperbaric spinal anesthesia with lidocaine, tetracaine, and bupivacaine. Reg Anesth Pain Med. 1998;23:159–63.View ArticlePubMedGoogle Scholar
- Gschwind YJ, Wolf I, Bridenbaugh SA, Kressig RW. Basis for a Swiss perspective on fall prevention in vulnerable older people. Swiss Med Wlkly. 2011;141:w13305.Google Scholar
- Haines TP, Hill AM, Hill KD, Brauer SG, Hoffmann TT, Etherton-Beer C, McPhail SM. Cost effectiveness of patient education for the prevention of falls in hospital: economic evaluation from a randomized controlled trial. BMC Med. 2013;11:135.View ArticlePubMedPubMed CentralGoogle Scholar
- Hariharan S, Zbar A. Risk scoring in perioperative and surgical intensive care patients: a review. Curr Surg. 2006;63:226–36.View ArticlePubMedGoogle Scholar
- Hempel S, Newberry S, Wang Z, Booth M, Shanman R, Johnsen B, Shier V, Saliba D, Spector WD, Ganz DA. Hospital fall prevention: a systematic review of implementation, components, adherence, and effectiveness. J Am Geriatr Soc. 2013;61:483–94.View ArticlePubMedPubMed CentralGoogle Scholar
- Ikutomo H, Nagai K, Nakagawa N, Masuhara K. Falls in patients after total hip arthroplasty in Japan. J Orthop Sci. 2015;20:663–8.View ArticlePubMedGoogle Scholar
- Imarengiaye CO, Song D, Prabhu AJ, Chung F. Spinal anesthesia: functional balance is impaired after clinical recovery. Anesthesiology. 2003;98:511–5.View ArticlePubMedGoogle Scholar
- Johnson RL, Kopp SL, Hebl JR, Erwin PJ, Mantilla CB. Falls and major orthopaedic surgery with peripheral nerve blockade: a systematic review and meta-analysis. Br J Anaesth. 2013;110:518–28.View ArticlePubMedPubMed CentralGoogle Scholar
- Marschollek M, Govercin M, Rust S, Gietzell M, Schulze M, Wolf KH, Steinhagen-Thiessen E. Mining geriatric assessment data for in-patient fall prediction models and high-risk subgroups. BMC Med Inform Decis Mak. 2012;14:12–9.Google Scholar
- Mion LC, Chandler AM, Waters TM, Dietrich MS, Kessler LA, Miller ST, Shorr RI. Is it possible to identify risks for injurious falls in hospitalized patients? Jt Comm J Qual Patient Saf. 2012;38:408–513.PubMedPubMed CentralGoogle Scholar
- Muraskin SI, Conrad B, Zheng N, Morey TE, Enneking FK. Falls associated with lower-extremity-nerve blocks: a pilot investigation of mechanisms. Reg Anesth Pain Med. 2007;32:67–72.PubMedGoogle Scholar
- Oliver D, Healey F, Haines TP. Preventing falls and fall-related injuries in hospitals. Clin Geriatr Med. 2010;26:645–92.View ArticlePubMedGoogle Scholar
- Rubenstein LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing. 2006;35:ii37–41.View ArticlePubMedGoogle Scholar
- Sharma S, Lorio R, Specht LM, Davies-Lepie S, Healy WL. Complications of femoral nerve block for total knee arthroplasty. Clin Orthop Relat Res. 2010;468:135–40.View ArticlePubMedPubMed CentralGoogle Scholar
- Suarez A, Macadar O. The effect of general and spinal anesthesia on balance control in elderly patients. Int Tinnitus J. 2008;14:146–51.PubMedGoogle Scholar
- Wasserstein D, Farlinger C, Brull R, Mahomed N, Gandhi R. Advanced age, obesity and continuous femoral nerve blockade are independent risk factors for inpatient falls after primary total knee arthroplasty. J Arthroplasty. 2013;28:1121–4.View ArticlePubMedGoogle Scholar